T细胞基础生物学：从起源到功能 - 知乎 - 知乎专栏
2019年12月20日 · pre-TCR复合物在DN胸腺细胞中的信号传递促进了β选择过程，从而指示细胞发生增殖爆发，并抑制进一步的β链重排。 β选择之后，胸腺细胞开始表达CD4和CD8，称之为 …
The structural basis for autonomous dimerization of the pre-T ... - Nature
2010年10月13日 · The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR β-selection, survival …
Pre-T cell receptor self-MHC sampling restricts thymocyte ...
2022年11月21日 · Signalling through the pre-T cell receptor (preTCR), a CD3-associated heterodimer comprising an invariant pTα chain and a clone-specific β chain, is a critical early …
Structure and function of the pre-T cell receptor - PubMed
The pre-T cell receptor (pre-TCR) that minimally consists of the TCR beta chain and the disulfide-linked pre-T cell receptor alpha (pT alpha) chain in association with signal-transducing CD3 …
Pre–T cell receptors topologically sample self-ligands ... - Science
2021年1月8日 · Self-discrimination, a critical but ill-defined molecular process programmed during thymocyte development, requires myriad pre–T cell receptors (preTCRs) and αβTCRs. Using …
免疫学笔记-1 | T细胞分化发育及其Marker - 简书
2020年11月12日 · αβT细胞表达的β链与pre-T细胞α链（pTα）组装成前TCR（pTα:β），成功表达前TCR的细胞即为pre-T细胞。 CD4+CD8+双阳性细胞阶段 ：在IL-7等细胞因子的诱导 …
Unique features of the pre-T-cell receptor α-chain: not just a ...
2005年7月1日 · The pre-T-cell receptor (pre-TCR) has a crucial role in the normal development of αβ T cells. Different views have emerged concerning the structure and function of the pre-TCR.
Science｜解析preTCR-pΜΗC复合物结构|细胞|蛋白|介导|抗原_网易 …
2020年12月19日 · 在preTCR介导的信号成功激活后，经过基因重排的TCR-α链会取代preTα链并与TCR-β形成新的二聚体，即具有能识别抗原的TCRαβ。 随后，表达成熟TCRαβ 的 T细胞逐步进 …
The pre-T cell receptor (TCR) complex is functionally coupled
1995年11月1日 · The pre-T cell receptor (TCR) complex regulates early T cell development and consists of a heterodimer of the TCR-beta subunit in association with the pre-TCR-alpha …
Pre–T-cell receptor binds MHC: Implications for thymocyte ... - PNAS
2015年7月7日 · There, CD4 – CD8 – double-negative (DN) thymocytes that generate a functional T-cell receptor (TCR) β-chain express on their surface the pre-TCR (preTCR). Unlike the TCR …