iC3b - Wikipedia
iC3b is a protein fragment that is part of the complement system, a component of the vertebrate immune system. iC3b is produced when complement factor I cleaves C3b. [1] Complement …
补体系统：机体免疫的重要防线 - 知乎
补体分子的受体及相关生物学作用 C3b和C4b（后者仅由经典途径产生）结合到CR1，而iC3b结合到CR3（Mac-1）和CR4。 CR1本身在诱导C3b包裹的微生物的吞噬作用方面效率不高，但如 …
The crystal structure of iC3b-CR3 αI reveals a modular recognition …
2022年4月12日 · Recognition of iC3b by complement receptor type 3 (CR3) fosters pathogen opsonophagocytosis by macrophages and the stimulation of adaptive immunity by …
Cleavage of Complement C3b to iC3b on the Surface of
2022年5月4日 · C3b cleavage to iC3b occurred quickly on the surface of S. aureus in human serum, similar to the iC3b generation observed on EA. Unlike the case for EA, in which all C3b …
医学免疫学中iC3b是什么 - 百度知道
C3 是一种β 球蛋白,由α和β两条多肽链组成,分子量分别是110kD和75kD.α链有998个氨基酸残基,β链有669个氨基酸残基；两链间以氢键、疏水键及二硫键相连,相互平行.α链参与C3活化,链 …
iC3b-CR3 αI 的晶体结构揭示了 CR3 整合素受体对主要调理素 iC3b …
细胞表面的补体激活导致 C3b、iC3b 和 C3dg（主要的补体调理素）大量沉积。 3 型补体受体 (CR3) 对 iC3b 的识别促进了巨噬细胞对病原体的调理吞噬和补体调理抗原对适应性免疫的刺激。
IC3b - an overview | ScienceDirect Topics
CR3 is a β 2-integrin that mediates binding of neutrophils to endothelial cells and is critical for neutrophil recruitment to sites of infection. CR3 mediates phagocytosis of iC3b-coated …
Moieties of Complement iC3b Recognized by the I-domain of …
2020年12月12日 · Complement fragment iC3b serves as a major opsonin for facilitating phagocytosis via its interaction with complement receptors CR3 and CR4, also known by their …
Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b
2021年6月15日 · Upon interaction with CR3, iC3b rearranges to form a compact receptor–ligand complex. Overall, the data suggest that the iC3b–CR3 interaction is of high affinity and relies …
Structural implications for the formation and function of the ...
2017年4月4日 · Complement-mediated opsonization, phagocytosis, and immune stimulation are critical processes in host defense and homeostasis, with the complement activation fragment …