EIF4E with 7MetGTP 4EBP (red) bound to the alpha helices (cyan) of eIF4E. Eukaryotic translation initiation factor 4E , also known as eIF4E , is a protein that in humans is encoded by the EIF4E gene .

真核起始因子4E（英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种帽结合蛋白，可以特异性地识别mRNA的5'端的帽子结构，它在真核翻译的起始过程中发挥重要作用。

真核起始因子4E （英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种帽结合蛋白，可以特异性地识别mRNA的5'端的帽子结构，它在真核翻译的起始过程中发挥重要作用。

翻译起始的速率主要取决于三聚物蛋白复合体eIF4F 对 5’ cap 的识别，eIF4F 组分包括：可以结合 5ʹ cap的eIF4E； 前导序列中解旋复合体二级结构所必需的解旋酶eIF4A；eIF4G，一种大型支架蛋白，可将 mRNA 转运至 eIF3 并通过结合多聚 A 结合蛋白 (PABP) 介导 mRNA 环化。

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA translation has been clearly assessed in the last decades. eIF4E function is essential for numerous physiological processes, such as protein synthesis, ...

2024年12月24日 · EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity).

2023年8月23日 · In this review, we summarize the biological functions and the research progress of eIF4E, the main influencing factors of eIF4E activity, and the recent progress of drugs targeting eIF4E, in the hope of providing new insights for the treatment of multiple malignancies and development of targeted drugs.

真核翻译起始因子 4E： 该基因编码的蛋白质是真核翻译起始因子 4F 复合体的一个组成部分，它识别信使 RNA 5' 端的 7-甲基鸟苷帽结构。编码的蛋白质通过将核糖体募集到 5'-帽结构来帮助翻译起始。这种蛋白质与 4F 复合物的结合是翻译起始的限速步骤。该基因作为原癌基因，其表达和激 …

2004年5月25日 · This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly ...

eIF4E is a critical node in an RNA regulon impacting cell cycle progression. eIF4E coordinately promotes mRNA export of cell cycle genes. eIF4E moves human epithelial cells along the cancer pathway by profoundly altering ribosomal recruitment to cancer-related transcripts