聚焦激酶：EGFR、KRAS - 知乎
①EGFR抑制剂：激活RAS突变对上游的EGFR或RTK阻断具有结构性抵抗力。 随着KRAS抑制剂的出现，人们对用KRAS抑制剂双重阻断RTK或EGFR也有一些研究实验。
Feedback activation of EGFR/wild-type RAS signaling axis limits ...
2023年4月5日 · Through a drug-anchored synthetic lethality screen, we discovered that epidermal growth factor receptor (EGFR) inhibition was synthetic lethal with MRTX1133. Mechanistically, …
Targeting EGFR and RAS/RAF Signaling in the Treatment of
The epidermal growth factor receptor (EGFR) and RAS/RAF signaling pathway plays pivotal roles in tumor progression via proliferation, survival, invasion, and immune evasion. Two anti-EGFR …
The intersection of EGFR and the Ras signaling pathway
2008年1月1日 · Here we highlight one important aspect of EGFR signaling, the bi-directional interaction between EGFR and Ras. We discuss the mechanistic basis for this interaction, its …
Dynamic Multilevel Regulation of EGFR, KRAS, and MYC …
This review presents an overview of recent findings on various epigenetic and post-transcriptional modifications of the epidermal growth factor receptor (EGFR), which activates the oncogenes …
Identification of RAS mutant biomarkers for EGFR inhibitor …
We recently combined mathematical modeling of RAS signaling network biochemistry with experimental cancer cell biology to determine why KRAS G13D is a biomarker for sensitivity to …
Targeting the EGFR/RAS/RAF signaling pathway in anticancer
Covalent, allosteric, or combinationaltherapies, along with PROTAC degraders, are key methods to addressresistance and toxicity in KRAS and BRAF inhibitors. Keywords: BRAF; EGFR; …
Epidermal Growth Factor Receptor Cell Proliferation Signaling …
Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and …
解码EGFR：揭开肿瘤治疗的下一个革命之门 - DXY.cn
2023年11月27日 · EGFR下游信号通路： 1、Ras/Raf/MEK/ERK (MAPK) 通路 EGFR的磷酸化吸引并激活了Grb2和SOS蛋白。 SOS进一步激活了Ras蛋白。 活化的Ras激活Raf。 Raf激 …
表皮生长因子受体 (EGFR) 信号传导 - MilliporeSigma
ErbB 家族由四种受体组成，包括 EGFR (ErbB-1/HER1)、ErbB-2 (Neu，HER2)、ErbB-3 (HER3) 和 ErbB-4 (HER4)。 该受体酪氨酸激酶家族 (RTK) 具有胞外配体结合结构域、疏水跨膜结构 …