抗突变型瓜氨酸波形蛋白抗体（抗mcv）是 类风湿 关节炎患者血清中的一种自身抗体，属于瓜氨酸相关自身抗体的一种。mcv是波形蛋白经由肽酰精氨酸亚氨酶(pad)的瓜氨酸化后蛋白结构发生变化，增加了潜在的抗原决定簇(瓜氨酸)，波形蛋白在凋亡细胞内因得不到 ...

抗突变型瓜氨酸波形蛋白(Anti-Mutated Citrullinated Vimentin, MCV)属于ACPAs 家 族，有研究表明其在诊断早期RA 灵敏度及特异度均较高，且与临床表现、疾病活动度相关[5]。

The goal of the study was to evaluate the diagnostic and prognostic value of anti-mutated citrullinated vimentin (anti-MCV) antibodies in juvenile idiopathic arthritis (JIA) comparing to anti-cyclic citrullinated peptide (anti-CCP). Thirty children with confirmed JIA …

随着对抗瓜氨酸蛋白抗体（acpa）研究的深入，抗突变型瓜氨酸波形蛋白（mcv）抗体作为acpa中的新成员受到越来越多的关注。抗mcv抗体较抗ccp抗体具有更多的瓜氨酸抗原决定簇，在ra的诊断中具有更高的敏感度和特异度，且与ra病情活动度相关 [4] 。

The presence of anti-CCP and anti-MCV antibodies, both of which are anti-citrulline protein antibodies, plays an important role in the early diagnosis of RA. The sensitivity and specificity of anti-MCV have been differentially indicated in various studies.

We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid ...

最近几年一种新的诊断标记物———抗突变型瓜氨酸化波形蛋白（抗MCV）的出现给早期RA诊断提供了一个全新的选择。在获得与抗CCP同样高的特异性的同时，抗MCV抗体的检测可以获得很好的敏感性（80%左右）。 德国 Orgentec 推出这一产品后，迅速引起高度的关注 ...

Objectives: To evaluates the diagnostic performance of the anti-CCP2, anti-CCP3 and anti-mutated citrullinated vimentin (anti-MCV) tests in differentiating rheumatoid arthritis (RA) from other forms of arthritis in a clinical setting of early arthritis.

Anti-MCV antibodies recognize a protein that originates from apoptotic macrophages and is present in the synovium of patients with RA. Nicaise Roland and colleagues investigated the usefulness of...

Mutated citrullinated vimentin or MCV is the native target antigen for autoantibodies to citrullinated proteins. It is present in the synovial tissues and synovial fluid of RA patients. MCV plays a central role in the pathogenesis of RA and is involved in the initiation of ACPA production.