Xin Gu, Ph.D. joined Harvard Medical School and Dana-Farber Cancer Institute as an Assistant Professor of Cell Biology in September 2024. She received her Bachelor of Science degree in Biology at Peking University, then obtained her Ph.D. …

Assistant Professor of Cell Biology (Harvard Medical School) Xin Gu, Ph.D., joined Harvard Medical School and Dana-Farber Cancer Institute in 2024. She received her Bachelor of Science degree in Biology at Peking University, then obtained her Ph.D. in Biology at Massachusetts Institute of Technology.

The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade numerous stimulus-responsive and cell-type specific transcription factors including EGR1, IRF4 ...

Xin Gu. Dana Farber Cancer Institute, Harvard Medical School. Verified email at hms.harvard.edu - Homepage. Cell Biology Biochemistry Physiology Cancer Biology. Articles Cited by Public access. Title. Sort. Sort by citations Sort by year Sort by title. Cited by. Cited by. Year; SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.

The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade numerous stimulus-responsive and cell-type specific transcription factors including EGR1, IRF4 ...

Welcome to the Gu Lab! We elucidate molecular mechanisms that are key for cellular homeostasis, with our initial effort on nuclear protein turnover by a novel ubiquitin-independent pathway: the midnolin-proteasome pathway.

For fellow personal and demographic information, contact HMS Human Resources at human_resources @hms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappt @hms.harvard.edu.

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The Gu lab will characterize the midnolin-proteasome pathway using biochemical, structural, and cellular experiments. Additionally, genetically engineered animal models will be used to determine the roles of midnolin in organismal physiology and pathology.

Dr. Xin Gu is an Expert appointed by UNESCO 2005 Convention on the Protection and Promotion of Diversity of Cultural Expression (since 2019). She is Director of the Master of Cultural and Creative Industries (MCCI) at Monash University in Australia.