WNT4 is a secreted protein that, in humans, is encoded by the WNT4 gene, found on chromosome 1. [5] [6] It promotes female sex development and represses male sex …

2025年3月30日 · WNT4 (Wnt Family Member 4) is a Protein Coding gene. Diseases associated with WNT4 include 46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs …

The WNT4 gene belongs to a family of WNT genes that play critical roles in development before birth. Learn about this gene and related health conditions.

2025年3月3日 · The WNT4 gene suppresses male sex differentiation pathways and promotes the formation of Müllerian duct structures, including the uterus and fallopian tubes, which are need …

WNT4 deficiency is caused by mutations of the WNT4 gene. Abnormally high androgen levels are found in the blood and can initiate and promote the development of male sex characteristics. …

2011年11月10日 · We report that Wnt4 was necessary for normal thymocyte and TEC numbers, as well as for the establishment of a proper medulla during fetal thymopoiesis and postnatal …

2012年9月20日 · Wnt4, initially required in both sexes for formation of the mullerian duct, appears to suppress the development of Leydig cells in the developing ovary. Consequently, Wnt4 …

2024年1月17日 · WNT4 regulates breast and gynecologic cancer metabolism via a previously unappreciated intracellular signaling mechanism at the mitochondria, with WNT4 mediating …

WNT4 - Explore an overview of WNT4, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.

2022年5月13日 · Rational: Wnt4 plays a critical role in development and is reactivated during fibrotic injury; however, the role of Wnt4 in cardiac repair remains unclear. In this study, our …