2. EMT 与 Wnt/β-catenin 通路. EMT 受多种信号通路调节，例如 TGF-β 、Wnt/β-catenin、 Hedgehog 和 Notch 信号通路 ，这些途径通过刺激 Snail 、 Twist 和 ZEB1/2 等转录因子来触发 EMT。在所有信号通路中，Wnt/β-catenin 通路在 EMT 的调控中发挥着关键作用[6]。 2.1 Wnt/β-catenin 的激活 ...

简单来说，当细胞没有接受Wnt信号刺激时 (Wnt Off)，细胞质内的Axin、APC和GSK3β形成毁灭复合体（destruction complex），与β-Catenin结合并使其被磷酸化后，最终通过泛素化修饰而降解。

• TGFβ信号-OVOL2双负反馈环在乳腺癌上皮-间质转化（EMT）中的作用机制. 2.Wnt信号通路. Wnt信号通路不仅在胚胎发育中发挥了一定的作用，而且与许多人类肿瘤的发生发展也有密切联系。例如在乳腺癌、大肠癌、肺癌、前列腺癌、黑色素瘤中均发现Wnt的过量表达。

2023年11月10日 · EMT 受多种信号通路调节，例如 TGF-β、Wnt/β-catenin、Hedgehog 和 Notch 信号通路，这些途径通过刺激 Snail、Twist 和 ZEB1/2 等转录因子来触发 EMT。 在所有信号通路中，Wnt/β-catenin 通路在 EMT 的调控中发挥着关键作用 [6] 。

2022年1月3日 · sFRPs, WIF, glypicans, Tiki, and Notum are well-known regulators of Wnt/β-catenin signalling that target Wnt proteins to affect signal transduction. sFRPs have a Netrin-related motif in the C...

2024年6月1日 · Persistent Wnt/β-catenin signalling facilitates the epithelial-mesenchymal transition (EMT), which accelerates CRC invasion and metastasis. This review provides a summary of recent molecular studies on the role of the Wnt/β-catenin signalling axis in regulating EMT in CRC cells, which triggers metastatic pathogenesis.

6 天之前 · Wnt signaling pathways are essential for various biological functions, including tissue homeostasis maintenance and embryonic development [1, 2].Disruption of these pathways can lead to various diseases [3, 4], most notably cancer [5, 6], where it plays a role in cancer initiation [7, 8], progression [], and metastasis [10, 11].The sensitivity of cancer cells to Wnt signaling is a …

4 天之前 · The Wnt signaling pathway is critically involved in orchestrating cellular functions such as proliferation, migration, survival, and cell fate determination during development. Given its pivotal ...

2025年3月14日 · Similarly, the oncogenic miR-103 targets and downregulates the tumor suppressor kruppel like factor 7 (KLF7), activating Wnt/β-catenin signaling to induce EMT . In contrast, some miRNAs act as tumor-suppressors by directly or …

HKDC1 modulated EMT and increased glycolysis through the Wnt/β-catenin signaling pathway. HKDC1 knockdown inhibited CRC tumor growth in vivo, whereas its overexpression promoted tumor progression. HKDC1 interacted with RCOR1 to upregulate its expression, activating the Wnt/β-catenin pathway and promoting CRC cell proliferation, migration, and ...