Wapl is an essential regulator of chromatin structure and …
2013年8月25日 · Depletion of the cohesin-associated protein Wapl in mice is shown to increase the residence time of cohesin on DNA, which leads to clustering of cohesin in axial structures, …
Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl
2017年4月19日 · The distribution of cohesin in the mouse genome depends on CTCF, transcription and the cohesin release factor Wapl. Cohesin and CTCF are known to spatially …
Wapl repression by Pax5 promotes V gene recombination by Igh …
2020年7月1日 · Reduced Wapl expression causes global alterations in the chromosome architecture, indicating that the potential to recombine all V genes entails structural changes of …
The cohesin release factor Wapl interacts with Bub3 to govern …
2020年4月8日 · To investigate the potential role of Wapl during meiotic maturation, we first examined its subcellular localization in mouse oocytes. We microinjected Wapl–green …
WAPL functions as a rheostat of Protocadherin isoform diversity …
We propose a model in which WAPL functions as a rheostat of cohesin processivity on DNA to enable structural and transcriptional modularity of the Pcdh gene cluster required to establish …
WAPL Gene - GeneCards | WAPL Protein | WAPL Antibody
2025年3月30日 · WAPL (WAPL Cohesin Release Factor) is a Protein Coding gene. Diseases associated with WAPL include Cornelia De Lange Syndrome and Mullegama-Klein-Martinez …
Wapl releases Scc1-cohesin and regulates chromosome structure …
2020年4月6日 · Here, we show that Wapl is required for accurate meiosis I chromosome segregation, predominantly releases Scc1-cohesin from chromosomes, and promotes …
Wapl is an essential regulator of chromatin structure and
2013年9月26日 · In mitosis, Wapl-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase, thus …
In mitosis, Wapl-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase, thus enabling …
Decreasing Wapl dosage partially corrects embryonic growth and …
2022年11月30日 · Haploinsufficiency for NIPBL causes a developmental disorder, Cornelia de Lange syndrome (CdLS), that is modeled by Nipbl +/− mice. Mutations in WAPL have not …