Unifiram (developmental code name DM-232) is an experimental drug. [1] that has antiamnesic and other effects in animal studies with far greater potency than piracetam. [2] [3] A number of related compounds are known, such as sunifiram (DM-235) and sapunifiram (MN-19).

2025年3月15日 · Unifiram (DM-232) is an experimental nootropic drug that enhances memory and cognitive function by modulating AMPA receptors and increasing acetylcholine levels in the brain, which makes Unifiram significantly more potent than Piracetam according to animal studies.

DM232 (unifiram) and DM235 (sunifiram) are potent cognition‐enhancers, which are four order of magnitude more potent than piracetam. These compounds, although not showing affinity in binding studies for the most important central receptors or channels, are able to prevent amnesia induced by modulation of several neurotransmission systems.

Unifiram (DM232) is acts as a potent cognition enhancer through the activation of the AMPA-mediated neurotransmission system. Unifiram (DM232) has the potential for amnesia prevention and neurodegenerative disorder research.

2002年7月24日 · These results indicate DM232 (unifiram) as a novel cognition enhancer, strictly related to piracetam-like compounds, able to ameliorate memory impairment at doses about 1,000 times lower than the most active available nootropic compounds.

DM232 (unifiram) and DM235 (sunifiram) are potent cognition-enhancers, which are four order of magnitude more potent than piracetam. These compounds, although not showing affinity in binding studies for the most important central receptors or channels, are able to prevent amnesia induced by modulation of several neurotransmission systems.

2023年5月31日 · Sunifiram and Unifiram are two closely related nootropics that have been garnering attention in recent years. We demystify these two intriguing substances by delving into their mechanisms, comparing their cognitive benefits, and discussing potential side effects.

Unifiram | C13H15FN2O3S | CID 9861054 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2004年1月2日 · Structure–activity relationships on two novel potent cognition enhancing drugs, unifiram (DM232, 1) and sunifiram (DM235, 2), are reported. Although none of the compounds synthesised reached the potency of the parent drugs, some fairly active compounds have been identified that may represent new leads to develop other cognition enhancing drugs.

2008年12月1日 · A series of amides, structurally related to DM232 (unifiram) and DM235 (sunifiram), characterized by a 1,2,3,4-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one, 1,4-diamino-cyclohexane or 1,4-diaminobenzene ring, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good ...