UL16 binding protein 1 (ULBP1) is a cell surface glycoprotein encoded by ULBP1 gene located on the chromosome 6. [5] [6] ULBP1 is related to MHC class I molecules, but its gene maps outside the MHC locus. [5] [6] The domain structure of ULBP1 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 ...

2024年12月25日 · ULBP1 (UL16 Binding Protein 1) is a Protein Coding gene. Diseases associated with ULBP1 include Nasopharyngeal Carcinoma and Myeloma, Multiple. Among its related pathways are Innate Immune System and Class I …

UL16结合蛋白-1（UL16-binding protein 1， ULBP1）是NKG2D ligand家族蛋白的成员之一，亦称NKG2DL，属于MHC-I类相关分子的新家族。 ULBP1编码基因位于6q24.2-6q25.3。 ULBPs都具有相似的结构特征，包括一个信号肽序列、一个α1域、一个α2域和一个细胞膜锚定区域 （图2） [5]。 ULBP1-4不含跨膜结构域，只能通过GPI与细胞膜相连。 各ULBPs分子与受体NKG2D的亲和力不同。 ULBP1蛋白可以通过结合NKG2D激活NK细胞、CD8+ T细胞和γδT细胞，从而参与 …

ULBPs可表达于多种肿瘤细胞的表面，不仅是NKG2D的功能性配体，而且可能还可以通过TCRγδ1途径直接激活 γδT细胞，并在抗肿瘤的免疫反应中发挥重要的作用。 ULBPs (又称为RAET1分子)作为一类新发现的人NKG2D配体家族日益受到关注。 该基因家族业已报道的成员有ULBP1 (RAET1I)、ULBP2 (RAET1H)、ULBP3 (RAET1N) …

该基因编码的蛋白质是第 2 组自然杀伤细胞 D 成员 (NKG2D) 的配体，NKG2D 是 NK 细胞和 T 细胞上的一种免疫系统激活受体。 编码的配体与 NKG2D 的结合导致几种信号转导通路的激活，包括 JAK2、STAT5、ERK 和 PI3K 激酶/ Akt。 此外，在巨细胞病毒感染的细胞中，该配体结合 UL16 糖蛋白并被阻止激活免疫系统。 已发现该基因的三个转录变体编码不同的亚型。 [RefSeq 提供，2015 年 11 月]

2025年2月8日 · ULBP1 binds to the NKG2D receptor and activates multiple signaling pathways in primary natural killer cells. The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells.

2020年6月23日 · UL-16 binding protein 1 (ULBP1) is a ligand of the activatory receptor Natural Killer cell Group 2 receptor D (NKG2D) and is found as a cell-surface protein on some malignant cells including on human hepatocellular carcinomas. We aimed to explore the biological and clinical significance of NKG2D ligands in the circulation of patients with HCC.

Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein (s) are secreted or actually retained in intracellular locations or membrane-attached.

UL-16 binding protein 1 (ULBP1) is a ligand of the activatory receptor Natural Killer cell Group 2 receptor D (NKG2D) and is found as a cell-surface protein on some malignant cells including on human hepatocellular carcinomas. We aimed to explore the biological and clinical significance of NKG2D ligands in the circulation of patients with HCC.

ULBP1配体可激活自然杀伤细胞（NK）和CD8+T细胞的NKG2D受体，从而触发免疫杀伤。 研究人员发现，ULBP1在子痫前期（PE）患者外周血外泌体中的高表达，可能会为PE的诊治提供一定依据。 此外，有关实验数据表明ULBP1在人类肝细胞癌（HCC）中大量表达。 且NKG2D受体和ULBP1的表达与HCC炎性细胞的存在密切相关。 另有研究提示，肝切除术后的早期复发与ULBP1的表达缺失密切相关。 因此，ULBP1有望成为HCC免疫治疗的分子靶点。 CSB …