Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5 ...
Consistent with the role of DDX5 in T-ALL and AML, using a DDX5-targeting human mAb (2F5), Wu et al. demonstrated that (1) 2F5 selectively inhibits acute promyelocytic leukemia (APL) …
DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 ...
2024年1月5日 · DDX5 serves as a molecular switch to regulate inflammation during bacterial infection. DDX5 promotes the modification of TLR2/4 mRNA with N6-methyladenosine, …
DDX5 plays essential transcriptional and post-transcriptional roles …
2019年5月23日 · We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis. Moreover, DDX5 regulates expression of cell cycle genes in …
DDX5 RNA Helicases: Emerging Roles in Viral Infection - MDPI
2018年4月9日 · Asp-Glu-Ala-Asp (DEAD)-box polypeptide 5 (DDX5), also called p68, is a prototypical member of the large ATP-dependent RNA helicases family and is known to …
Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA …
2023年8月19日 · In this review, we discuss the multifaceted functions of DDX5 in DNA repair in cancer, immune suppression, oncogenic metabolic rewiring, virus infection promotion, and …
RNA binding protein DDX5 directs tuft cell specification and …
Results: DDX5 ΔIEC mice harboured a loss of intestinal tuft cell populations, modified microbial repertoire, and altered susceptibilities to ileal inflammation and colonic tumourigenesis. …
The RNA helicase p68 (DDX5) is selectively required for the
2012年9月17日 · The RNA helicase p68 (DDX5) is an established co-activator of the p53 tumour suppressor that itself has a pivotal role in orchestrating the cellular response to DNA...
死盒解旋酶 5（DDX5）基因 | MCE - MCE-生物活性分子大师
死盒解旋酶 5： 该基因编码 RNA 解旋酶 DEAD 盒家族的成员，由于其作为衔接分子的作用，参与多种细胞过程，促进与大量其他因素的相互作用。 这种蛋白质参与包括 RNA 结构改变在内的 …
Circulation 上海交通大学医学院附属瑞金医院张瑞岩/闫小响团队阐明心肌细胞中DDX5 …
2024年7月30日 · 首次报道RNA解旋酶DDX5在维持心脏功能中的关键作用，阐明DDX5通过调节心肌细胞CaMKIIδ可变剪接维持细胞钙稳态的深层机制。 心力衰竭 (Heart Failure)，简称心衰， …
科学家揭示DDX5对体细胞重编程的关键作用—论文—科学网
2017年1月20日 · 研究发现，DDX5功能缺失上调RYBP，从而进一步促进了组蛋白H2A赖氨酸K119位点的泛素化 (H2AK119ub1)的水平，并促进H2AK119ub1富集到部分胚层分化特异基因 …