Tropomyosin receptor kinase B - Wikipedia
Tropomyosin receptor kinase B (TrkB), [5] [6] [7] also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a …
北京大学第六医院司天梅/李继涛团队揭示BDNF-TrkB通路在早期 …
认知功能障碍是指与学习记忆以及思维判断有关的大脑高级智能加工过程出现异常，导致患者日常生活、社会交往和工作能力明显减退的综合征，目前认知功能障碍的病因及发病机制尚不明 …
Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy …
Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein, has been found to play a pivotal role in neural development. This protein is encoded by the neurotrophic receptor …
TrkB transmembrane domain: bridging structural understanding …
2024年3月2日 · TrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal …
TrkB/BDNF signaling pathway and its small molecular agonists in …
2024年1月1日 · Mature neurotrophic factors primarily function as non-covalently linked homodimers, such as NT-3/NT-3. However, some neurotrophic factors can also form …
Regulation of BDNF-TrkB Signaling and Potential Therapeutic …
Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, …
The trkB Tyrosine Protein Kinase Is a Receptor for Brain-Derived ...
Summary. trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that encodes a receptor for nerve growth factor (NGF) and neurotrophin-3 (NT-3).trkB expression …
Regulation of TrkB cell surface expression—a mechanism for
2020年6月15日 · Neurotrophin signaling via receptor tyrosine kinases is essential for the development and function of the nervous system in vertebrates. TrkB activation and signaling …
《细胞》：抗抑郁药物作用机制大揭秘——直接结合TrkB受体
2021年3月6日 · 然而，近期来自芬兰赫尔辛基大学的Eero Castrén团队发现，这些 抗抑郁药物可以直接与BDNF的受体TrkB结合，提高TrkB在膜表面的表达量从而增强BDNF的 ...
TrkB signalling pathways in LTP and learning - Nature
In recent years, a role has been proposed for the neurotrophin receptor tyrosine kinase TrkB in synaptic plasticity, learning and memory. Liliana Minichiello discusses the signalling pathways ...