Trikafta has proven to do great things for my health. Mentally though it had put me through some dark times where i didn’t really want to do anything i enjoyed. me and my doctors communicated, and with permission i only take one Trikafta in the mornings when i usually take it.

2021年2月16日 · "Canadian research released in August 2020 demonstrates that if Trikafta was brought to Canada quickly, as it has been in the United States, the United Kingdom and parts of Europe already, it could result in extraordinary health benefits by 2030, including 15% fewer deaths, 60% fewer people living with severe lung disease and an increased estimated median age of survival for a child born with ...

2019年11月21日 · So I started Trikafta 5 days ago and the side effects are crazy. I was diagnosed late and I have a mild CF. (F508del + 3600G ->A) Lately I find myself forgetting things, having difficulty following shows or books and just generally in a fog.

2020年7月1日 · When I started Trikafta, this same pain started day 2 and lasted for a week. Can't sleep, can't get comfortable, forced myself to eat to take Trikafta. It hasnt come back in 8 months. However, in the few months that followed, I did get diarrhea, cramps, and bloating. I still have some upper abdominal bloating, but no pain.

2022年10月19日 · I had an ADHD diagnosis before Trikafta. I had to increase my ADHD medication dose for the first time in 8 years after starting Trikafta. Speaking with a few physicians I know, many have had patients that now need ADHD medication and/or insomnia medication after starting Trikafta. The effect also seems stronger in women than men.

2024年3月15日 · After starting trikafta, it took about a year for me to accept that i can actually do something with my life and that i deserve it after all the hell i went through with cf things and others. I’m now into year 3 of trikafta and ive started studying nursing and dropped from working horrible jobs full time to 4 casual jobs that all bring me joy.

2022年4月26日 · One of my mutations is r117h which makes it progress relatively slower and hurt less. I don’t have many lung issues at all (yet) but it is probably inevitable as I get older. My issues are primarily in my GI and I get recurring pancreatitis attacks. I started on trikafta with hopes that these issues might go away (they have almost entirely).

2021年11月12日 · Germany and Finland have Trikafta (it's called Kafrio in Europe). Finland has a very small CF population (estimated 100-150 people) due to the mutation being rare there, so some things are a bit harder to get by, depending on where you live. To my knowledge, there is one CF center in the whole country, which is in the capital (Helsinki).

Vertexs newest triple therapy which has recently completed phase 3 trials: Vanzacaftor + tezacaftor + deutivacaftor proved to be "superior" to Trikafta / Kaftrio ( Elexacaftor + tezacaftor + Ivacaftor ). The pivotal phase 3 trials saw an improvement on FEV1 and reducing sweat chloride levels when compared to Trikafta / Kaftrio:

Seville oranges, usually by way of marmalade. Star fruits, as well-- they actually affect cytochrome P450 3A (CYP3A for short; this is the enzyme that helps metabolize Trikafta and other CFTR modulators as well as most drugs) more than grapefruit, if I recall correctly. Pomegranate juice has some effect as well.