We have compared the effectiveness of TRH and a rat hypothalamic PRL-releasing factor (PRF; previously incubated with rat serum to destroy TRH) in stimulating the release of PRL into the plasma of conscious lactating rats when injected before and after pituitary PRL had been depleted and transformed …

In mammals, TRH acts as a PRF that promotes prolactin release , and it is regulated by a cascade of several different signaling pathways, including those that regulate TRH-induced prolactin synthesis and secretion. When TRH is coupled to the Gq protein, it binds to the Gq protein-coupled TRH receptor and is able to induce MEKK activation via ...

2013年9月5日 · 下丘脑促垂体区肽能神经元分泌的肽类激素，主要作用是调节腺垂体的活动，因此称为下丘脑调节肽（hypothalamus regulatory peptide,HRP）。 近20多年来，从下丘脑组织提取肽类激素获得成功，并已能人工合成。 1968年Guillemin实验室从30万只羊的下丘脑中成功地分离出几毫克的促甲状腺激素释放激素（TRH）,并在一年后确定其化学结构为三肽。 在这一生成成果鼓舞下，Schally实验室致力于促性腺激素释放激素（GnRH）的提取工作。 1971年他们从16万 …

下丘脑调节肽包括九种，分别是促甲状腺激素释放激素（trh）、促性腺激素释放激素（gnrh）、生长激素释放抑制激素即生长抑素（ghrih）、生长激素释放激素(ghrh)、促肾上腺皮质激素释放激素（crh）、促黑素细胞激素释放因子（mrf）、促黑素细胞激素释放抑制 ...

In 1971, Tashjian et al. described TRH as a potent prolactin-releasing factor (PRF), and since then, TRH has become one of the best-studied PRFs (Fig. 3.12). However, it is still not clear whether TRH is a physiologic regulator of prolactin. Most likely, TRH is one of the regulators, but not the primary releasing factor (Tashjian et al., 1971).

随后，又在下丘脑提取液中发现还有一咱能促进腺垂体释放PRL的因子，称为催乳素释放因子（prolactin releasingfactor,PRF）。 将下丘脑提取液中的TRH分离出去，仍具有PRF活性，说明下丘脑提取液中PRF活性不是来自TRH。

1) The rat posterior pituitary contains a potent PRF capable of inducing a rapid, hormone-specific, concentration-dependent stimulation of PRL release from perifused anterior pituitary cells. 2) The MBH contains significantly less PRF activity, which is largely attributable to TRH.

Extracts of porcine hypothalamic fragments (HF) bring about the release of prolactin when injected into estrogen-progesterone pretreated male rats. To determine the extent to which this prolactin-releasing activity (PRA) is attributable to thyrotropin-releasing hormone (TRH) and/or vasopressin (VP), …

2021年5月22日 · 促甲状腺激素释放激素thyrotropin-releasing hormone(TRH)是三肽，其化学结构为：（焦）谷-组-脯-NH2. TRH主要作用于腺垂体促进促甲状腺激素（TSH）释放，血中T4和T3随TSH浓度上升而增加。给人和动物静脉注射TRH（1mg），1-2min内血浆TSH浓度便开始增加，10-20min达高峰，TSH的 ...

下丘脑 促 垂体 区 肽能神经元 分泌的肽类 激素，主要作用是调节 腺垂体 的活动，因此称为 下丘脑调节肽 （hypothalamus regulatory peptide,HRP）。 近20多年来，从下 丘脑 组织提取肽类激素获得成功，并已能人工合成。 1968年Guillemin实验室从30万只羊的下丘脑中成功地分离出几毫克的 促甲状腺激素释放激素 （TRH）,并在一年后确定其 化学 结构为 三肽。 在这一生成成果鼓舞下，Schally实验室致力于 促性腺激素释放激素 （GnRH）的提取工作。 1971年他们从16万头猪 …