重新审视CD8+ Tregs：具有不同表型和特性的异质群体
2022年8月30日 · Tregs是免疫抑制性T细胞，在预防自身免疫和病原体诱导的免疫病理学方面发挥关键作用，从而维持免疫稳态和自我耐受。 具有抑制活性的 CD8+ T 细胞在20世纪70年代就 …
CD8+ Tregs revisited: A heterogeneous population with different ...
We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this …
Revival of CD8+ Treg–mediated suppression: Trends in Immunology
Recent studies of these lymphocytes, now popularly referred to as regulatory CD8 + T cells (CD8 + Tregs), have helped clarify their important role in the regulation of autoimmune disease. …
Future prospects for CD8+ regulatory T cells in immune tolerance
In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8 + and CD4 + Tregs, and we will discuss …
Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for ...
The primary function of Treg is to maintain immune homeostasis and self-tolerance by modulating the activity of effector lymphocyte populations. Traditionally, both CD4 + and CD8 + Treg have …
Frontiers | CD8+ Regulatory T Cell – A Mystery to Be Revealed
2021年8月17日 · Various CD8 + T cell subsets carrying certain regulatory properties have been discovered in different experimental systems and have been named “CD8 + Tregs” (Table 1). …
Tissue‐Resident Memory CD8+ T Cells: Differentiation, Phenotypic ...
2025年3月10日 · CD8+ tissue-resident memory T cells (TRM) are strategically located in peripheral tissues, enabling a rapid response to local infections, which is different from …
Nature Immunology｜CD4+和CD8+Treg细胞在控制自身反应性免 …
2025年2月17日 · CRISPR-Cas9基因编辑 研究者利用Cas9核蛋白（RNP）电穿孔技术，在人类扁桃体T细胞中敲除FOXP3或GZMB基因，以研究CD4+ Treg和CD8+ Treg的功能缺失对免疫反 …
CD8+ Tregs in autoimmunity: learning “self”-control from …
CD8 + T regulatory cells (Tregs) mediate immune suppression through various cell contact-dependent and independent mechanisms. a CD8 + Treg interacts with an autoantigen-loaded …
Advances on CD8+ Treg Cells and Their Potential in Transplantation
In this review, we will focus on recent advances on CD8 Treg cells and description of a role for CD8 Treg cells in tolerance in both solid organ transplantation and graft-versus-host disease …