Type II topoisomerase - Wikipedia
Type II topoisomerases are topoisomerases that cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use the hydrolysis of ATP, unlike Type I …
拓扑异构酶 - 百度百科
拓扑异构酶（topoisomerase）是指通过切断 DNA 的一条或两条链中的 磷酸二酯键，然后重新缠绕和封口来更正DNA 连环数 的酶。 DNA拓扑异构酶 是存在于 细胞核 内的一类酶，他们能够 …
Topoisomerase II inhibitors design: Early studies and new …
2023年7月1日 · Numerous cancer chemotherapeutic drugs target Topo II enzymes. Selective targeting of Topo II for cancer treatment is an active field in research. Anthracyclines, …
II 型 DNA 拓扑异构酶 | DNA topoisomerase II (topo II) | MCE
DNA topoisomerase II (topo II) are essential and ubiquitous enzymes that perform important intracellular roles in chromosome condensation and segregation, and in regulating DNA …
A Mini Review of Novel Topoisomerase II Inhibitors as Future …
Topo II catalytic inhibitors destroy cancer cells through the inhibitions of Topo II enzymatic activities, thus preventing the formation of Topo II–DNA complex without increasing DNA …
Topoisomerase II and etoposide — a tangled tale
2023年1月30日 · Etoposide, a chemotherapeutic poison of type IIA eukaryotic topoisomerases (topo IIs), promotes topo II to compact DNA by trapping DNA loops, creates DNA double …
DNA topoisomerase II and its growing repertoire of biological
2009年4月20日 · Type II topoisomerases change DNA topology by generating transient DNA double strand breaks and are essential for all eukaryotic cells. Mammalian cells have two …
拓扑异构酶I (type I topoisomerase, Top1) 催化产生DNA分子上的单链缺口,而拓扑异构酶II (type II topoisomerase, Top2) 则催化产生DNA 分子上的双链缺口。 Top2 在哺乳动物中又分为α 亚型 …
Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II
Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA superhelicity and unlink double-stranded DNA segments during processes such as replication …
II 型 DNA 拓扑异构酶 | Type II DNA topoisomerase (topo II) | MCE
Type II DNA topoisomerase (topo II) is a type IIA topoisomerase that can relax both positively and negatively supercoiled DNA in an ATP- and Mg 2+-dependent manner. Topo II is required for …