Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene. [5][6][7] It is an inhibitory adaptor protein within Toll-like receptors (TLR). [8] .

TLR 信号转导通路的激活来源于细胞浆 Toll/IL-1 受体 (TIR) 的结构域，该结构域与 TIR 结构域包含的接头蛋白 MyD88 发生相互作用。 经过配体的刺激，通过两个分子死亡结构域的相互作用，MyD88 将 IL-1 受体相关激酶-4 (IRAK-4) 吸引到 TLRs。 IRAK-1 经磷酸化而激活并与 TRAF6 发生作用，从而激活 IKK 复合体并导致 MAP 激酶 (JNK, p38 MAPK) 和 NF-κB 的激活。 Tollip 和 IRAK-M 均与 IRAK-1 相互作用，并负性调节 TLR 介导的信号转导通路。

2025年3月30日 · TOLLIP (Toll Interacting Protein) is a Protein Coding gene. Diseases associated with TOLLIP include Lymphoproliferative Syndrome, X-Linked, 1 and Idiopathic Interstitial Pneumonia. Among its related pathways are Innate Immune System …

2020年1月14日 · 闫楠课题组通过CRISPR-Cas9全基因组文库筛选鉴定出维持STING蛋白稳态的一个关键蛋白TOLLIP。 TOLLIP能够在静止状态下（无病原菌感染）维持STING蛋白的稳定和机体整个免疫系统的平衡。 TOLLIP敲低或者敲除显著降低STING的表达，从而抑制了DNA刺激引起的免疫应答反应（cGAS-STING信号通路）。 作者发现，TOLLIP可以和STING相互作用，从而抑制STING被溶酶体降解。 为了进一步研究STING溶酶体降解的信号调控途径，作者发现 …

2024年3月25日 · Toll-interacting protein (TOLLIP) prevents inflammation and lipid accumulation in alveolar macrophages to limit integrated stress response activation, macrophage necrosis...

2012年2月1日 · The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane trafficking processes through its interaction with both proteins and phosphoinositides. Here, I discuss the multitasking role of Tollip associated with its modular architecture.

In this study, we identify Toll-interacting protein (TOLLIP) as a negative regulator of RLR signaling. A deficiency of TOLLIP leads to an enhanced type I interferon response upon RNA viral infection. Mice with the deletion of TOLLIP are more resistant to lethal vesicular stomatitis virus (VSV) infection than wild-type counterparts.

2020年10月31日 · TOLLIP protein level is increased in monocyte-derived dendritic cells treated with HIV-1 particles and recombinant gp120 glycoprotein, supporting a potential function of TOLLIP in modulating human responses to HIV infection .

TOLLIP (Toll-interacting protein) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type–specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic-reticulum stress, an activator of autophagy, or a critical regulator of intracellular vacuole trafficking.

该基因编码一种泛素结合蛋白，该蛋白与多种 Toll 样受体 (TLR) 信号级联组分相互作用。 编码的蛋白质调节炎症信号，并参与白细胞介素 1 受体运输和 IL1R 相关激酶的转换。 已发现该基因编码不同亚型的几种转录变体。 [RefSeq 提供，2016 年 1 月] This gene encodes a ubiquitin-binding protein that interacts with several Toll-like Receptor (TLR) signaling cascade components.