Tofisopam [3] (Emandaxin, Grandaxin, Sériel) is an anxiolytic that is marketed in several European countries. [4] Chemically, it is a 2,3-benzodiazepine. Unlike other anxiolytic benzodiazepines (which are generally 1,4- or 1,5-substituted) however, tofisopam does not have anticonvulsant , sedative , [ 5 ] skeletal muscle relaxant , motor skill ...

2011年1月20日 · Tofisopam (marketed under brand names Emandaxin and Grandaxin) is a 2,3-benzodiazepine drug which is a benzodiazepine derivative. In contrast to classical 1,4-benzodiazepines, the compound does not bind to the benzodiazepine...

Tofisopam, a 2,3-benzodiazepine with anxiolytic properties, has been shown to exert in vitro anti-inflammatory and immunomodulatory effects. The present study investigates the potential of tofisopam as a protective adjuvant against isoprenaline-induced MI in rats and explores the possible underlying mechanisms.

托非索泮（英語： Tofisopam 、Emandaxin、Grandaxin、Sériel）是一种含氮有机化合物 [3] ，化学式C 22 H 26 N 2 O 4 [4] ，属于苯二氮䓬类药物，在欧洲作为抗焦慮藥销售。

2024年1月18日 · Tofisopam is an atypical benzodiazepine used for attenuating the effects of other benzodiazepine sedatives or muscle relaxants. Here's what you need to know.

Tofisopam, a 2,3-benzodiazepine (2,3-BDZs), represent a unique drug among CNS-active compounds. Though sharing a common chemical backbone to ‘classical’ 1,4-benzodiazepines and though sharing the anxiolytic activity, the compound does not interact with the benzodiazepine binding site of the γ-aminobutyric acid (GABA) receptor (Petocz 1993 ...

New clinical reports have recently been published on tofisopam—an anxiolytic drug currently registered as a benzodiazepine—after a long break in this research area. Neurobiological studies concerning its properties, which differ from those of benzodiazepines, are underway.

Tofisopam (marketed under brand names Emandaxin and Grandaxin) is a 2,3-benzodiazepine drug which is a benzodiazepine derivative. In contrast to classical 1,4-benzodiazepines, the compound does not bind to the benzodiazepine binding site of the gamma-aminobutyric acid receptor and its psychopharmacological profile differs from such compounds.

Tofisopam is a benzodiazepine derivative with anxiolytic (anti-anxiety) properties. It belongs to the class of psychoactive drugs and is primarily used for the management of anxiety disorders. -Tofisopam is indicated for the treatment of generalized anxiety disorder and other conditions characterized by excessive and persistent worry or anxiety.

托非索泮 （Tofisopam），主要用于治疗 焦虑状态，亦曾试用于治疗 抑郁症。 本药品被归类到 抑郁症 等药品分类。 同 地西泮。 但与传统的苯二氮卓类比较，思睡的 副作用 少见也不明显，老年病人除外。 注意：同种药品可由于不同的包装规格有不同的用法或用量。 本文只供参考。 如果不确定，请参看药品随带的说明书或向医生询问。 常用量：50mg/次，3次/d，口服；重症患者可用至300mg/d。 类似 地西泮，但基本上没有 镇静 、抗 惊厥 和 肌肉 松弛作用。 包装规格：50mg …