
TIRAP - Wikipedia
TIRAP (TIR domain containing adaptor protein) is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns.
含衔接蛋白的 TIR 结构域(TIRAP)基因 | MCE
该基因编码的蛋白质是参与免疫系统 TLR4 信号通路的 TIR 衔接蛋白。 它激活 NF-kappa-B、MAPK1、MAPK3 和 JNK,然后导致细胞因子分泌和炎症反应。 该基因的选择性剪接会产生多种转录本变体;然而,并非所有变体都得到了充分描述。 [RefSeq 提供,2008 年 7 月] The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns.
TIRAP Gene - GeneCards | TIRAP Protein | TIRAP Antibody
2025年3月30日 · TIRAP (TIR Domain Containing Adaptor Protein) is a Protein Coding gene. Diseases associated with TIRAP include Bacteremia 1 and Malaria. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.
TIRAP - 华文百科
Tirap (含有衔接蛋白的TIR结构域)是与收费类受体相关的衔接子分子。 先天免疫系统通过Toll样受体(TLR)识别微生物病原体,该病原体鉴定了与病原体相关的分子模式。
TIRAP: an adapter molecule in the Toll signaling pathway
2001年9月1日 · We have identified and characterized a Toll–interleukin 1 receptor (TIR) domain–containing adapter protein (TIRAP) and have shown that it controls activation of MyD88-independent signaling ...
TIRAP: how Toll receptors fraternize - Nature Immunology
2001年9月1日 · TIRAP mediates a transmembrane signal that results in the activation of downstream signal transduction events independently of MyD88. As suggested by its name, TIRAP was discovered by virtue of...
TIRAP in the Mechanism of Inflammation - PMC - PubMed …
The Toll-interleukin-1 Receptor (TIR) domain-containing adaptor protein (TIRAP) represents a key intracellular signalling molecule regulating diverse immune responses. Its capacity to function as an adaptor molecule has been widely investigated in ...
TIRAP in the Mechanism of Inflammation - Frontiers
2021年7月7日 · TIRAP, also known as MyD88-adaptor Like (MAL), is an adapter molecule associated with receptor-mediated activation of host immune signaling (1, 2). The innate immune system recognizes microbial pathogens through receptors, including Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns (PAMP) (3, 4). Upon ligation of ...
TIRAP, TRAM, and Toll-Like Receptors: The Untold Story
While the crucial role of Myd88 is well described, the contribution of other adaptors in mediating TLR signaling and function has been underestimated. In this review, we highlight important results demonstrating that TIRAP and TRAM adaptors are also required for full signaling activity and responses induced by most TLRs. 1. Introduction
Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor ...
2025年2月8日 · Study reports that, in response to natural activators of innate immunity, the sorting adaptor TIRAP regulates TLR signaling from the plasma membrane and endosomes. TIRAP plays a central role in regulating the effects of lipopolysaccharides or lipoteichoic acid on chlorpromazine-induced hepatotoxicity.