Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets .

血小板生成素(thrombopoietin, TPO)是有生理学意义的血小板生成调节因子。尽管1950年代就提出类似于促红细胞生成素(erythropoietin, EPO)的血小板生长因子的概念，但直到1994年才证实这种造血生长因子的存在，并提纯此蛋白质。

2025年2月3日 · 促血小板生成素 （英语： Thrombopoietin，缩写为“ THPO ”），亦作“ 巨核细胞生长衍生因子 ”（MGDF），是一种人体内由促血小板生成素（THPO） 基因 编码的类 激素。 其化学本质为 糖蛋白，主要由肾脏和肝脏分泌，能刺激可以产生大量血小板的 巨核细胞 的形成和分化，进而促进血小板的生成 [1]。 这种蛋白质是 MLP/C_MPL 的 配体。 MLP/C_MPL 是一种骨髓增生性白血病病毒癌基因的表达产物 [2]。 编码促血小板生成素的基因位于人 3号染色体 的长臂 …

2024年3月6日 · 血小板是血液中的一种组成部分，主要功能是防止出血，促血小板生成素（TPO）也称为巨核细胞生长发育因子，是由肝脏实质细胞、肝窦内皮细胞和肾小管细胞产生的糖蛋白激素。 通过结合和激活 TPO 受体（c-mpl)，刺激巨核细胞增殖、成熟、分化，参与并调节血小板生成全过程。 血液中TPO的水平和血小板数量呈负相关。 当血小板增多时，由血小板介导的TPO代谢清除量增多，血液中TPO的水平下降，反之血液中TPO水平升高。 2. 血清中TPO水 …

Thrombopoietin (TPO) is the principal physiologic regulator of platelet production. In vitro, TPO induces the growth of colony-forming units-megakaryocyte (CFU-MK) and the generation of mature polyploid megakaryocytes, which subsequently form extended cytoplasmic processes, termed proplatelets.

Thrombopoietin, the primary regulator of blood platelet production, was postulated to exist in 1958, but was only proven to exist when the cDNA for the hormone was cloned in 1994. Since its initial cloning and characterization, the hormone has revealed many surprises.

2002年11月15日 · Thrombopoietin (TPO), the c-Mpl ligand, is the primary physiologic regulator of megakaryocyte and platelet development. Since the purification of TPO in 1994, 2 recombinant forms of the c-Mpl ligand—recombinant human thrombopoietin (rhTPO) and pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF)—have ...

Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. There is no "sensor" of the platelet count; …

Factors which have now been implicated in at least some aspects of thrombocyte development include IL-3, IL-6, IL-9, IL-11, G-CSF, GM-CSF, SCF, leukemia inhibiting factor, and TPO. The latter molecule is believed to be of paramount importance …

Thrombopoietin (Tpo) is the primary physiological hormone, which regulates all aspects of megakaryocyte and platelet development. Tpo interacts with its receptor, Mpl, on the cell surface of megakaryocyte precursors, mature megakaryocytes, and platelets to stimulate megakaryocyte progenitor proliferation and maturation, megakaryocyte polyploidy ...