LC3-associated endocytosis facilitates extracellular Tau aggregate ...
2025年2月12日 · We demonstrated that microglial cells internalize extracellular Tau that colocalized with LC3 containing endosomes showing LC3-associated Tau endocytosis …
CCT2 is an aggrephagy receptor for clearance of solid protein ...
2022年4月1日 · CCT2 colocalized with Tau (P301L) aggregates and promoted LC3 recruitment to the aggregates. We observed multiple puncta triple positive for Tau (P301L), CCT2, and LC3 …
Disease‐associated tau impairs mitophagy by inhibiting Parkin ...
2018年12月11日 · The ubiquitin chains thus generated can interact with autophagy adaptors, recruiting LC3 (microtubule‐associated protein 1A/1B‐light chain 3)‐positive autophagosomal …
Prolonged tau clearance and stress vulnerability rescue by ...
2020年6月26日 · In these patient-derived cell models that express tau at endogenous levels and recapitulate disease-relevant phenotypes 21, 37, we measured ALP markers including the …
2024年12月6日 · Microtubule-associated protein 1 light chain 3 (LC3)-associated endocytosis (LANDO) is a recently discovered microglial mechanism for an effective clearance of A …
LC3-associated endocytosis facilitates extracellular Tau aggregate ...
2024年12月11日 · Results: We analyzed microglial activation by measuring the upregulation of Ionized Calcium-binding Adapter Molecule 1 (Iba-1) expression. Later, we demonstrated the …
Neuroinflammation-Modulating Agent SB1617 Enhances LC3 …
2023年11月28日 · Our results indicated that SB1617-mediated microglial surveillance with LC3-associated phagocytosis is a critical molecular mechanism in the regulation of tau …
Strain-specific clearance of seed-dependent tau aggregation by …
2021年3月5日 · Effect of Li on seed-dependent tau aggregates was explored in neuronal cells. Li reduced insoluble tau and p62, and increased LC3-II and the number of AVs. The effects were …
神经炎症调节剂 SB1617 增强 LC3 相关吞噬作用以缓解 tau 病 …
2023年11月28日 · Our results indicated that SB1617-mediated microglial surveillance with LC3-associated phagocytosis is a critical molecular mechanism in the regulation of tau …
Promoting tau secretion and propagation by hyperactive …
2020年1月6日 · We investigated the relationship between p300/CBP activity, the autophagy-lysosomal pathway (ALP) and tau secretion in mouse models of tauopathy and in cultured …