7186 22030 Ensembl ENSG00000127191 ENSMUSG00000026942 UniProt Q12933 P39429 RefSeq (mRNA) NM_021138 NM_009422 NM_001290413 RefSeq (protein) NP_066961 NP_001277342 NP_033448 Location (UCSC) Chr 9: 136.88 – 136.93 Mb Chr 2: 25.41 – 25.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene ...

TNF 受体相关因子 2： 该基因编码的蛋白质是 TNF 受体相关因子 (TRAF) 蛋白质家族的成员。 TRAF 蛋白与 TNF 受体超家族成员结合并介导信号转导。该蛋白直接与 TNF 受体相互作用，并与 TRAF1 形成异二聚体复合物。这种蛋白质是 TNF-α 介导的 MAPK8/JNK 和 NF-kappaB 激活所必需的。由该蛋白和 TRAF1 形成的蛋白 ...

Jul 22, 2015 · 导的分支点.本文主要阐述traf2的分子结构及它的结构与功能的关系,tnf信号传导的分子机制及. traf2在其中的作用,重点关注traf2作为凋亡途径和nf-κb介导的存活途径,即这2条相互拮抗的信号. 传导途径的分支点的重要性. 关键词:traf2;信号传导;调控

肿瘤坏死因子受体相关因子(tumor necrosis factor receptor-associated factors, TRAF)是一类重要的具有多功能的细胞内信号转导因子。TRAF参与多种受体家族的信号转导，包括肿瘤坏死因子受体家族(tumor necrosis factor receptor, TNFR)和Toll样-IL-1受体(Toll-like receptors-interleukin-1 receptors,TLR-IL-1R)家族等，在固有免疫和获得性 ...

Apr 20, 2023 · TRAF2 (Tumor necrosis factor receptor-associated factor 2) is a dual function protein, acting as an adaptor protein and a ubiquitin E3 ligase, which plays an essential role in mediating the TNFα ...

TRAF2 expression in various normal human tissues and its association with diseases. (A) mRNA expression profile of TRAF2 in normal human tissues.(B) Protein expression data of TRAF2 in normal human tissues.(C) Representative IHC images of TRAF2 expression in normal stomach, lung, ovary, cervix, liver, kidney, rectum, and esophagus.(D) Disease network map of associated diseases of TRAF2, with ...

Mar 30, 2025 · TRAF2 (TNF Receptor Associated Factor 2) is a Protein Coding gene. Diseases associated with TRAF2 include Myeloma, Multiple and Hematologic Cancer.Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.Gene Ontology (GO) annotations related to this gene include identical protein binding and …

The most important TRAF2-interacting E3 ligases are cIAP1 and cIAP2. Prominent substrates of the TRAF2-cIAP1/2 complex are kinases, such as transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1), NFκB-inducing kinase (NIK), apoptosis signal-regulating kinase 1 (ASK1), and receptor-interacting kinase 1(RIPK1), which regulate NFκB signaling and induction of programmed cell death.

TRAF2 and TRAF5 are closely related members of the TRAF family of proteins. They are important signal transducers for a wide range of TNF receptor superfamily members, in cluding TNFR1, TNFR2, CD40 and other lymphocyte costimulatory receptors, RANK/TRANCE-R, EDAR, LTβR, LMP-1 and IRE1. TRAF2 and TRAF5 therefore regulate diverse physiological roles, ranging from T and B cell signaling and ...

Jan 8, 2024 · 3. TRAF2在体外和体内以p62依赖的方式促进肿瘤生长. 由于p62是TRAF2的底物，作者接下来研究了p62在TRAF2敲除肝癌细胞中的作用机制，发现在TRAF2缺失的细胞中，p62的敲低促进了肝癌细胞的生长和存活，表明p62起抑制生长的作用。