细胞中抑制癌变的基因“tp53”会判断dna变异的程度，如果变异较小，这种基因就促使细胞自我修复，若dna变异较大，“tp53”就诱导细胞凋亡。 在人的基因里面，TP53是非常重要的抑癌基因，在正常细胞中低表达，在恶性肿瘤中高表达。

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. [5] .

2025年3月30日 · p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage). Activation of p53 occurs by several mechanisms including phosphorylation by …

2017年11月13日 · TP53基因，又称为p53基因，是因为编码一种分子量为53kDa的蛋白质而得名。 被作为著名的“抑癌基因”而被广泛研究。 简单来说，TP53基因编码的p53蛋白其中的重要作用之一是调控细胞分裂和增殖。

tp53基因可以在多个肿瘤类型里发生，不同肿瘤类型中tp53基因的突变频率不同，最高的是子宫癌肉瘤，肺腺癌居中也达到了60%多（见图3）。 TP53基因在约90%的小细胞肺癌（ SCLC ）和约50%的非小细胞肺癌（ NSCLC ）中发生改变。

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …

The TP53 Database compiles various types of data and information from the literature and generalist databases on human TP53 gene variations related to cancer. The database is hosted by the National Cancer Institute (NCI) of the United States.

2023年3月1日 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key structural features of...

TP53，是17号染色体的基因，该基因编码一种包含转录激活、DNA结合和寡聚结构域的抑癌蛋白。