Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6]

Tumor necrosis factor alpha (TNF-α) is a cytokine that has pleiotropic effects on various cell types. It has been identified as a major regulator of inflammatory responses and is known to be involved in the pathogenesis of some inflammatory and autoimmune diseases .

Jun 2, 2022 · TNF inhibitors work by blocking the activity of a protein called TNFα. This protein normally helps with important functions such as fat metabolism and blood clotting, and excess TNFa can contribute to chronic inflammation and joint damage—as is the case in RA and other autoimmune conditions.

Dec 19, 2023 · Tumor necrosis factor (TNF) is a type of protein that helps support your body's immune response. It is key to the inflammation process that supports healing when your body is attacked by trauma or disease.

Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its family members and its biological and pathological functions.

Tumor Necrosis Factor Alpha (TNF-α) is a cytokine that acts as an arbitrator of the local tissue environment following injury, and is involved in bone tissue regeneration. It can initiate apoptosis and regulate cell survival and proliferation.

Aug 1, 2000 · This article will review the structure/function relationships of the TNF alpha and the TNF receptor superfamily. It will also discuss insights as to how structural features play a role in the pleiotropic effects of TNF alpha.

Mar 30, 2025 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

TNF-alfa inhibitors treat a wide range of inflammatory conditions such as rheumatoid arthritis (RA), psoriatic arthritis, juvenile arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, and psoriasis.

Tumor necrosis factor has direct, in vitro antitumor cytotoxicity on 30% to 50% of tumor cell lines, and it has been demonstrated to be active in vivo against both murine tumors and human tumor xenografts, particularly when they have reached a size of at least 5 mm in diameter. 90–93 Which of the pleiotropic biologic activities of TNF ...