Specifically, this study is designed to examine the possibility of TLR4 as a candidate receptor interacted with G. atrum polysaccharide (PSG-1) and elucidate the role of reactive oxygen …

2017年12月21日 · Here, we show that palmitate-stimulated CD11b + F4/80 low hepatic infiltrating macrophages, but not CD11b + F4/80 high Kupffer cells, generate ROS via dynamin-mediated …

2011年4月28日 · ECSIT- and TRAF6-depleted macrophages have decreased levels of TLR-induced ROS and are significantly impaired in their ability to kill intracellular bacteria. …

2020年5月21日 · We found that autophagy and ROS were required for S.pn -induced NETs formation. Moreover, TLR4 partly mediated NETs formation in response to S.pn in vitro and in …

在 GC 中激活 TLR4 信号后，会诱导更高水平的活性氧 (ROS)。 使用氧化酶抑制剂和抗氧化剂，我们发现线粒体 ROS (mROS) 是 TLR4 刺激 ROS 生成的主要来源。 这种升高的 mROS 产生 …

2015年8月31日 · In the present study, we demonstrate that the TLR4- and TLR2-induced IRAK-ERK pathway cross-talks with p67phox-Nox-2 for ROS generation, thus regulating IL-1β …

2021年7月30日 · Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing ROS generation

Post-reperfusion inflammation and an up-regulation of toll-like receptor 4 (TLR4), an upstream sensor of innate immunity, are associated with poor outcome in stroke patients. Here, we …

提示ROS信号参与Fn诱导的NETs形成。 2）Fn通过TLR4-ROS诱导NETs形成：①Fn刺激的NeuTLR4基因表达升高（Plt;0.001）；②TLR4抑制剂TAK-242可明显抑制Fn诱导的NETs形 …

ROS and RNS signaling were demonstrated to be related to TLR4-dependent NF-κB activation and inflammatory cytokines production (Weigert et al., 2018). The membrane-associated …