Role of MEK1 in TLR4 Mediated Signaling - PMC
TLR4 is the mammalian receptor recognizing bacterial lipopolysaccharide (LPS), the main cell wall component of Gram-negative bacteria, and plays a critical role in sepsis and controlling …
Co-inhibition of RAGE and TLR4 sensitizes pancreatic cancer to
2025年2月14日 · We demonstrated that autophagy activation can be attributed to increased expression of high-mobility group box 1 (HMGB1); co-inhibition of two HMGB1 receptors, …
Sorafenib inhibits LPS-induced inflammation by regulating Lyn …
Tyrosine kinase phosphorylation plays an important role in inflammatory mechanism, such as TLR4 tyrosine phosphorylation, MAPK pathway protein activation, and activation of …
Toll-like receptor 4 – a multifunctional virus recognition receptor
2024年8月22日 · TLR4 is a single-pass transmembrane protein whose structure and function as a pattern recognition receptor (PRR) are highly conserved in mammals. TLR4 can be located on …
Toll-like receptor 4: A potential therapeutic target for multiple …
2023年10月1日 · TLR4 has significant meaning in the occurrence and development of cardiovascular and cerebrovascular diseases. TLR4 plays an important role in the occurrence …
C-Type Lectin DC-SIGN Modulates Toll-like Receptor Signaling via Raf …
2007年5月25日 · We demonstrated that pathogens trigger DC-SIGN on human DCs to activate the serine and threonine kinase Raf-1, which subsequently leads to acetylation of the NF-κB …
SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells …
2023年10月16日 · Our data strongly suggest that SARS-CoV-2 interacts with the C-type lectin receptor DC-SIGN leading to Raf-1-mediated suppression of TLR4 signaling. We observed …
棉子糖通过调节肠道微生物群和靶向炎症 TLR4–MyD88–NF-κB 信 …
对肠道微生物群丰度及其与结肠炎参数的相关性的分析表明，Raf 部分缓解了 DSS 引起的生态失调。 总之，Raf 通过调节肠道微生物群和 TLR4-MyD88-NF-κB 通路对结肠炎发挥保护作用。
Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung ...
2018年9月1日 · Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling …
Rab26对TLR4介导的ARDS的作用及机制研究 – RAF信号通路
结论 rab26对tlr4所介导的ards炎性因子表达，以及激活下游信号通路有抑制作用，为将来急性肺损伤诊治的方向和重点进一步提供了研究依据。 Author admin Posted on December 11, 2023