The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 …
2009年3月1日 · The TLR4–MD-2–LPS structure illustrates the remarkable versatility of the ligand recognition mechanisms employed by the TLR family4,5, which is essential for defence …
TLR4-MD-2复合物识别脂多糖的结构基础,Nature - X-MOL
2009年3月1日 · Toll 样受体 (TLR) 4 和髓样分化因子 2 (MD-2) 形成异二聚体，可识别结构多样的 LPS 分子中的常见“模式”。 为了了解 TLR4-MD-2-LPS 复合物的配体特异性和受体激活机制， …
神奇的脂多糖 - 知乎 - 知乎专栏
MD2是一种特殊的外分泌蛋白，能帮助TLR4识别LPS。 3种蛋白质（CD14、TLR4和MD2）的不同组合决定了TLR4对不同结构LPS的识别能力，其中跨膜蛋白TLR4起关键作用。 当LPS …
RCSB PDB - 3FXI: Crystal structure of the human TLR4-human MD-2 …
2009年1月21日 · Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 (MD-2) form a heterodimer that recognizes a common 'pattern' in structurally diverse LPS molecules. To …
Artesunate: attenuating TLR4/MD2 signaling to alleviate cardiac ...
2025年1月31日 · Artesunate has been reported to inhibit the Toll-like receptor 4 (TLR4) pathway in macrophages after stimulation with lipopolysaccharide (LPS), which explains artesunate’s …
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 …
2009年4月30日 · Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 (MD-2) form a heterodimer that recognizes a common 'pattern' in structurally diverse LPS molecules. To …
Recognition of lipopolysaccharide pattern by TLR4 complexes
2013年12月6日 · In this review, we discuss the reported structures of the TLR4–MD-2 complex, LBP and CD14, and consider their implications for our understanding of TLR4–MD-2 activation …
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure …
2023年12月1日 · In this study, we used receptor structure-based VS and biological detection methods to obtain new TLR4/MD2 inhibitors with an anti-inflammatory activity. All the selected …
Key residues in TLR4-MD2 tetramer formation identified by free
2019年10月14日 · The key residues of TLR4 and TLR4* identified by per-residue free energy decomposition (kcal/mol) in the TLR4/TLR4* interface of ligand-free (TLR4-MD2)2 tetramer, …
MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll ...
Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently …