TLR4——细菌LPS的受体 - 知乎 - 知乎专栏
Toll 样受体 4 （Toll-like receptor 4，TLR4）是由 Poltorak 等于 1998 年发现的 一种 I 型跨膜蛋白，其由 TLR4 基因编码，并表达于包括单核细胞，巨嗜细胞在内 的多种组织细胞中，可以识 …
LPS/TLR4 signal transduction pathway - PubMed
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. …
An examination of the LPS-TLR4 immune response through the …
2025年3月18日 · The LPS-TLR4 immune response is a critical mechanism in the body's defense against Gram-negative bacterial infections, yet its dysregulation can lead to severe …
TLR4 and CD14 trafficking and its influence on LPS-induced pro ...
TLR4 is activated by lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria and sequentially triggers two signaling cascades: the first one involving TIRAP and MyD88 adaptor …
Recognition of lipopolysaccharide pattern by TLR4 complexes
2013年12月6日 · In this review, we summarize these structures and describe the structural basis of LPS recognition by LPS receptors and accessory proteins. In the initial phase of infection, …
Lipopolysaccharide (LPS)-binding protein stimulates CD14 …
Toll-like receptor 4 (TLR4) is an indispensable immune receptor for lipopolysaccharide (LPS), a major component of the Gram-negative bacterial cell wall. Following LPS stimulation, TLR4 …
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal ...
1999年4月16日 · TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been putatively identified as Lps, the gene necessary for potent responses to …
TLR4是内毒素（LPS）跨膜信号转导的关键受体 - 知乎
脂多糖 （lipopolysaccharide，LPS）是一种内毒素（Endotoxin），当其作用于人类或动物等其他生物细胞时，就会表现出多种的生物活性。LPS的生理作用是通过存在于宿主细胞的细胞膜表 …
TLR4: The Winding Road to the Discovery of the LPS Receptor
2016年10月1日 · Within a matter of weeks, Shizuo Akira’s group (6) confirmed that TLR4 was indeed the receptor for LPS and demonstrated this conclusively using functional and genetic …
Reconstruction of LPS Transfer Cascade Reveals Structural ... - PubMed
2017年1月17日 · Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, binds Toll-like receptor 4 (TLR4)-MD2 complex and activates innate …