TLR3 is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.

2024年1月22日 · 功能：TLR3的主要功能是识别病毒的双链RNA，一个典型的病毒遗传物质或复制中间体。当TLR3识别到dsRNA时，它会触发一系列免疫应答：信号传导激活： TLR3通过 TRIF 途径（TIR-domain-containing adapter-inducing interferon-β）传递信号，而不是通过许多其他TLR所使用的MyD88途径。

Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response. Studies have ...

2025年3月30日 · TLR3 (Toll Like Receptor 3) is a Protein Coding gene. Diseases associated with TLR3 include Immunodeficiency 83 Viral Infections and Human Immunodeficiency Virus Type 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll-Like receptor Signaling Pathways.

Gene ID: 7098, updated on 9-Feb-2025. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.

2021年9月12日 · 概要：Toll样受体3（TLR3）是TLR家族的成员，介导I型干扰素、促炎细胞因子和趋化因子的转录诱导，从而共同建立宿主的抗病毒反应。 研究表明，不同于其他TLR家族成员，TLR3是唯一一个完全依赖于β干扰素TIR结构域衔接蛋白（TRIF）的核糖核酸传感器。 然而，TLR3-TRIF信号通路如何在抗病毒反应中起作用以及如何被调控尚不完全清楚。 在这篇综述中，我们重点介绍了TRIF信号通路抗病毒机制的最新研究进展，并描述了TLR3的基本特征及其 …

2016年6月16日 · [摘要]Toll样受体（TLR）在机体防御外来病原微生物方面起到很重要的作用。 Toll样受体3（TLR3）能识别病毒. 素调节因子3（IRF3），导致目的基因的表达。 本文主要对TLR3的特征及其信号通路的相关进展作一综述。 therapidprogressinthepropertyandsignalingpathwayofTLR3．. TLR）家族，迄今已在人类中发现至少10种TLR。 为Toll／IL－1R（TIR）区域，与信号传导密切相关。 本文主要对TLR3及其信 …

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2023年1月11日 · Here, we report cryo-electron microscopy analyses of TLR3 complexed with longer dsRNA. TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative...