Our study indicates that STEAP3 serves as a novel negative regulator of pathological cardiac hypertrophy by blocking the activation of the Rac1-dependent signaling cascade and may contribute to exploring effective therapeutic strategies …

2021年11月5日 · STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in...

2023年6月23日 · STEAP3 is a novel biological marker for determining prognosis, and it also performs a remarkable function in the promotion of tumor growth in ccRCC by enhancing invasion and EMT, as well as by triggering the recruitment and polarization of M2 macrophages.

New research into highly expressed proteins in metastatic castration-resistant prostate cancer shows that Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) are significant drivers of prostate cancer aggressiveness and metastasis.

2025年3月30日 · STEAP3 (STEAP3 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP3 include Anemia, Hypochromic Microcytic, With Iron Overload 2 and Anemia, Congenital, Nonspherocytic Hemolytic, 2. Among its related pathways are Gene expression (Transcription) and Signaling by Rho GTPases.

2021年5月27日 · STEAP3. The STEAP3 gene is located on chromosome 2q14.2 and encodes an mRNA of 4.3 kb, generating a protein with 488 amino acids (UniProt ID: Q658P3, 54.601 kDa). The predicted structure of STEAP3 indicates six-transmembrane domains at C-terminal region, a cytosolic OxRD at the N-terminal counterpart and two conserved histidine residues .

2020年8月31日 · Our study indicates that STEAP3 serves as a novel negative regulator of pathological cardiac hypertrophy by blocking the activation of the Rac1-dependent signaling cascade and may contribute to exploring effective therapeutic strategies of pathological cardiac hypertrophy treatment.

2025年1月4日 · STEAP3 promotes cancer cell proliferation by facilitating nuclear trafficking of EGFR to enhance RAC1-ERK-STAT3 signaling in hepatocellular carcinoma.

STEAP3 modulates ERK and JNK signaling to promote stemness and cell cycle progression in HCC. To reveal how aberrant nuclear expression of STEAP3 promotes HCC cells proliferation, we first examined its modulation on stemness phenotype.

STEAP3 is a novel biological marker for determining prognosis, and it also performs a remarkable function in the promotion of tumor growth in ccRCC by enhancing invasion and EMT, as well as by triggering the recruitment and polarization of M2 macrophages.