2025年3月30日 · SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2) is a Protein Coding gene. Diseases associated with SREBF2 include Hypercholesterolemia, Familial, 1 and Combined Oxidative Phosphorylation Deficiency 8. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Metabolism of steroids.

Vergnes et al. reveal how loss of Srebp2 (Srebf2) in the mouse greatly compromises expression of both Srebp1a and Srebp1c in the liver (asterisk), which are cotranscribed from the same locus (Srebf1) and differ in their 5′ exons, causing defects in both hepatic cholesterol and fatty acid synthesis. Vergnes et al. also describe how defects in ...

Three homozygous variants (p.L604W, p.S517F, and p.T984A) within the sterol regulatory element-binding factor 2 (SREBF2) gene are identified in one autosomal recessive family and two sporadic patients, respectively.

2023年11月29日 · Cholesterol homeostasis is under tight regulation at the transcriptional and post-transcriptional level. Sterol regulatory element-binding protein 2 (SREBP2, encoded by the SREBF2 gene)...

2022年9月12日 · Chromatin immunoprecipitation sequencing (ChIP-seq) analyses reveals that sterol regulatory element-binding proteins (SREBPs), the master regulatory TFs of lipid metabolism, are preferentially...

2023年5月18日 · Here, we identify SREBP2 as a novel substrate for USP28, a deubiquitinating enzyme that is frequently upregulated in squamous cancers. Our results show that silencing of USP28 reduces expression...

2025年3月4日 · Title: Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities. Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.

SREBF2 is a prognostic marker in Kidney renal clear cell carcinoma, Lung squamous cell carcinoma

2025年1月5日 · SREBF2 triggers endoplasmic reticulum stress and Bax dysregulation to promote lipopolysaccharide-induced endothelial cell injury. Association of SREBF-2 gene polymorphisms with the risk of developing type 2 diabetes mellitus.

2011年3月2日 · The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus ...