Sertindole, sold under the brand name Serdolect among others, is an antipsychotic medication. Sertindole was developed by the Danish pharmaceutical company Lundbeck and marketed under license by Abbott Labs. Like other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of ...

舍吲哚是新开发的强效中枢性多巴胺D2和 5-羟色胺 （5-HT2） 受体拮抗剂，是 非典型抗精神病药物。 密闭，避光保存。 本品是苯吲哚衍生物，对5-HT2A和5-HT2C受体及多巴胺-D2受体和α1- 肾上腺素能受体 具有强的亲和力。 但是它对5-HT2比D2是低的，本品不能引起A9多巴胺神经元黑质纹状体途径去极化失活，意味着抗神经元不良反应低。 但是本品对A10神经元（中间边缘系和中间皮层的通路）有活性，意味着具有强抗精神病作用。 虽然对 去极化阻滞 的意义有一些争论， …

Sertindole is a second-generation antipsychotic recently reintroduced in the market for the treatment of schizophrenia after a reevaluation of its risks and benefits. 4 Our aim in this review is to provide an overview of the pharmacological properties of sertindole as well as of its efficacy, tolerability and safety profile. Moreover, to ...

Sertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia.

舍吲哚是一种非典型抗精神病药，2002 年因其心脏毒性作用退出欧洲市场，2005 年又重新引入欧洲市场。 近期 Zoccali 博士、Bruno 博士及 Muscatello 博士在 Journal of Clinical Psychopharmacology 杂志上发表文章，他们搜集了 PubMed 数据库中从 1990 年到 2014 年以英文出版的文章，并借鉴相关产品说明书，对舍吲哚的药理学性质、疗效、不良反应进行了综述。 舍吲哚对 5-HT 2A、5-HT 2C、多巴胺 D2 及α1 肾上腺素能受体具有高亲和性，对边缘系统中多 …

舍吲哚片 （Sertindole），商品名 塞丁道尔。 精神分裂症。 本药品被归类到 精神分裂症 等药品分类。 本品对 运动神经 的 不良反应 （锥体外系 综合征），明显低于 氟哌啶醇，与 安慰剂 无显著差别。 最重要的不良反应是男性 心排血量减少 和QTc间期平均延长11～21ms。 此外，还有 鼻粘膜 充血 和轻度 体重增加 （2～3kg）。 本品引起QTc间期延长已由几位有经验的 心脏病学 专家评价，尽管他们注意心律的变化，未发现伴随QTc间期延长的临床 心脏病 的 体征 和 症状 或任 …

相比之下，位列第三、第四的帕利哌酮（Paliperidone，PAL）和舍吲哚（Sertindole，SER），其分析结果基于近年来的研究数据，与安慰剂相比，表现出中等效果（SMD -0.43，95%CI -0.93至0.08 ；SMD -0.57，95%CI -1.03至 -0.11）。

Sertindole is an atypical antipsychotic reintroduced into the European market in 2005 after a reevaluation of its risks and benefits, under the agreement that close electrocardiographic screening would be conducted. It has a high affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and α1 adrenerg …

Sertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia.

Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials …