Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, …

The meaning of SENESCENCE is the state of being old : the process of becoming old or aging. How to use senescence in a sentence. Did you know?

Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease.

2021年7月13日 · Learn about cellular senescence, what it is and how NIA-funded research is exploring how understanding this process may contribute to healthy aging.

Aging is the time-related deterioration of the physiological functions necessary for survival and reproduction. The phenotypic changes of senescence (which affect all members of the species) are not to be confused with diseases of senescence, such as cancer and heart disease (which affect individuals).

2019年6月2日 · The term senescence is, in some ways, a synonym for biological aging. In fact, Merriam Webster defines it simply as the state of becoming old. In scientific terms, senescence refers to the state in which cells stop dividing and slip …

2020年12月16日 · Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to processes such as...

2022年8月3日 · Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. However, prolonged senescence can be maladaptive, leading to cancer...

2025年4月3日 · Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA...

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, …