SDHA is a tumour suppressor gene, and heterozygous carriers have an increased risk of paragangliomas as well as pheochromocytomas and renal cancer. [18] Risk management for …

SDH，即线粒体内膜结合酶复合物 (SDHA, SDHB, SDHC, SDHD and SDHAF2)，催化琥珀酸氧化成延胡索酸。 SDH复合物的突变常见于多种人类肿瘤，其突变造成琥珀酸积累，从而在结构 …

2025年3月30日 · SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A) is a Protein Coding gene. Diseases associated with SDHA include Cardiomyopathy, Dilated, 1Gg and …

The SDHA gene provides instructions for making one of four parts (subunits) of the succinate dehydrogenase (SDH) enzyme. The SDH enzyme plays a critical role in mitochondria, which …

2020年3月16日 · We find that Myc facilitates the acetylation-dependent deactivation of SDHA by activating the SKP2-mediated degradation of SIRT3 deacetylase. We further demonstrate that …

该基因编码琥珀酸泛醌氧化还原酶的主要催化亚基，是线粒体呼吸链的复合体。 该复合物由四个核编码亚基组成，位于线粒体内膜中。 该基因的突变与一种称为 Leigh 综合征的线粒体呼吸链 …

Knowing if you have an SDHA mutation can help you manage your medical care. If you know you have an SDHA mutation, it is important to find tumors early. It is also important to tell your …

In order of decreasing molecular mass, these are the flavoprotein subunit (SDHA), the iron sulfur protein subunit (SDHB; 185470), and the integral membrane protein subunits SDHC and …

Loss of SDHA expression identifies SDHA mutations in succinate dehydrogenase-deficient gastrointestinal stromal tumors. SDHA-negative gastrointestinal stromal tumors comprise …

2022年5月9日 · 复合物II 又称为 SDH，由四个亚基组成： SDHA - 它含有具有共价结合的 FAD （黄素腺嘌呤二核苷酸，F位点）的活性位点，并从琥珀酸盐中去除电子; SDHB - 具有三个 …