2013年8月25日 · Wapl depletion increased the mean Smc3-ChIP read density at the transcription start site (TSS) of many downregulated genes, including c-myc, and at non-TSS cohesin sites …

与此同时，SMC1-SMC3同时招募一个由Pds5和半翼蛋白(wings apart-like protein, Wapl)组成的异源二聚体（简称Pds5-Wapl），催化Rad21与SMC3之间的结合被拆开，这样一来粘合素环外 …

2014年7月17日 · Studies in fly and human have shown that this process involves the WAPL mediated opening of the cohesin ring at the junction between the SMC3 ATPase domain and …

2009年3月27日 · Scc3, Pds5, and Rad61 (Wapl) are regulatory subunits that control this process. We describe here smc3, scc3, pds5, and rad61 mutations that permit yeast cell proliferation …

Following DNA replication in S-phase, Smc3 acetylation in the head domain promotes the recruitment of Sororin (11–14), which binds Pds5 and counteracts Wapl activity, thereby …

2020年3月23日 · WAPL promotes rapid RAD51-dependent repair and restart of broken replication forks. We propose that active removal of cohesin allows cancer cells to overcome DNA …

2024年8月13日 · The ring-shaped Cohesin complex, consisting of core subunits Smc1, Smc3, Scc1, and SA2 (or its paralog SA1), topologically entraps two duplicated sister DNA molecules …

2014年11月11日 · To understand how the latter’s disconnection by the regulatory subunits Wapl, Pds5, and Scc3 releases cohesin from chromatin and how Smc3 acetylation locks rings shut …

2020年12月14日 · In this study, we used acute protein degradation to deplete WAPL in mouse embryonic stem cells (mESCs) to examine the immediate effects of changes in cohesin …

2016年2月18日 · We show that mutations capable of bypassing Eco1 in Smc1, Smc3, Scc1, Wapl, Pds5, and Scc3 subunits reduce dissociation of N-terminal cleavage fragments of Scc1 …