2019年10月11日 · In skeletal muscle fibers, ROS have been suggested to stimulate glucose transporter 4 (GLUT4)-dependent glucose transport during artificially evoked contraction ex vivo, but whether myocellular...

2024年11月1日 · ROS contribute to GLUT4 translocation that increases skeletal muscle glucose uptake during exercise and stimulate signalling pathways that increase GLUT4 expression. Conversely, ROS can also inhibit GLUT4 translocation …

Piperine in pepper prevents hyperglycemia by GLUT4 translocation through CaMKKβ/AMPK signaling via TRPV1-dependent increase in the intracellular Ca 2+ level and ROS generation.

Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce cellular damage and cell death. Increased mitochondrial ROS production is observed in a number of pathological conditions characterized by mitochondrial dysfunction.

GLUT4 mediates the effects of insulin, or insulin-like growth factor on regulations of cognition, memory, behavior, motor activity and seizures. GLUT4 positive neurons are responsible for glucose sensing. Physical activity improves GLUT4 translocation in neurons, a process that needs Rab10 phosphorylation.

2016年6月6日 · Reactive oxygen species (ROS) are involved in the stimulation of glucose transport in isolated skeletal muscle preparations during intense repeated contractions. Consistent with this observation, heavy exercise is associated with significant production of ROS.

2024年11月1日 · ROS contribute to GLUT4 translocation that increases skeletal muscle glucose uptake during exercise and stimulate signalling pathways that increase GLUT4 expression. Conversely, ROS can also inhibit GLUT4 translocation …

stimulate glucose transporter 4 (GLUT4)-dependent glucose transport during artificially evoked contraction ex vivo, but whether myocellular ROS production is stimulated by in vivo

2018年5月1日 · 在骨骼肌中，ROS 与孤立的电刺激肌肉中的葡萄糖转运有关，但在体内运动中 ROS 的确切来源以及它是否控制葡萄糖转运蛋白 4 (GLUT4) 对体内葡萄糖的摄取尚不清楚。 在这里，我们利用遗传编码的生物传感器、荧光染料和缺乏 NADPH 氧化酶 2 (NOX2) 调节亚基 p47phox 和 Rac1 的小鼠模型的组合来证明 NOX2 是骨骼肌体内跑步机运动过程中 ROS 的主要来源。 此外，p47phox 缺陷小鼠表型复制 Rac1 mKO 小鼠代谢失调的关键方面，包括体内葡萄 …

ros 有助于 glut4 易位，从而增加运动期间骨骼肌葡萄糖的摄取，并刺激增加 glut4 表达的信号通路。 相反，ROS 还可以抑制代谢疾病状态下的 GLUT4 易位和表达。