2025年3月30日 · RHOH (Ras Homolog Family Member H) is a Protein Coding gene. Diseases associated with RHOH include Immunodeficiency 129 and T-Cell Immunodeficiency With Epidermodysplasia Verruciformis. Among its related pathways are GPCR Pathway and Signaling by Rho GTPases.

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. [5] It is encoded by the gene RHOH .

2016年10月14日 · In this study, we report that RhoH deficiency promotes, and RhoH overexpression reduces, eosinophil differentiation in vitro and in vivo. Moreover, RhoH induces the developmentally important...

2024年11月16日 · RhoH is an atypical Rho family member that is always GTP-bound and thus always activated. It is restrictively expressed in normal hematopoietic cells, where it is a negative regulator of cell...

Real Husbands of Hollywood (abbreviated RHOH) is an American reality television parody that originally aired on BET from January 15, 2013, to December 13, 2016. [1] A revival series produced for streaming service BET+ premiered on February 10, 2022.

由该基因编码的蛋白质是三磷酸鸟苷 (GTP) 代谢酶 Ras 超家族的成员。 编码的蛋白质在造血细胞中表达，在那里它作为细胞生长和存活的负调节剂发挥作用。 该基因可能在白血病和淋巴瘤中过度突变或错误表达。 非霍奇金淋巴瘤中的染色体易位发生在该基因座和 3 号染色体上的 B 细胞 CLL/淋巴瘤 6 (BCL6) 之间，导致融合转录物的产生。 5' 非翻译区的可变剪接导致编码相同蛋白质的多个转录变体。 [RefSeq 提供，2013 年 5 月] The protein encoded by this gene is a …

As an atypical member of the Rho family small GTPases, RhoH shares less than 50% sequence similarity with other members, and its expression is commonly observed in the haematopoietic lineage. To date, RhoH function was observed in regulating T cell receptor signalling, and less is known in other haematopoietic cells.

2025年1月4日 · RhoH is a key adapter protein that maintains LCK in the inactive state, contributing to the regulation of both pre-TCR and TCR signalling during T-cell development. propose that RhoH functions as a negative regulator for IL3-induced signals through modulation of the JAK-STAT pathway

预测能够实现几个功能，包括GTP结合活性；GTP酶活性；和激酶抑制剂活性。 预测涉及几个过程，包括Rac蛋白信号传导；细胞骨架组织；和吞噬凋亡细胞。 预测位于细胞质和免疫突触。 预测在几个细胞组件中活跃，包括细胞皮质；细胞质囊泡；和细胞骨架。 这个基因的人类同源物与疣状皮肤病有关。 与人类RHOH（Ras同源家族成员H）正交。 [由基因组资源联盟，2022年4月提供] Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

2005年2月15日 · Rho guanosine triphosphatases (GT-Pases) are recognized as critical mediators of signaling pathways regulating actin assembly, migration, proliferation, and survival in hematopoietic cells. Here, we have studied a recently identified hematopoietic-specific Rho …