RAD52 homolog (S. cerevisiae), also known as RAD52, is a protein which in humans is encoded by the RAD52 gene. [5][6] The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination.

2024年4月24日 · RAD52 is important for the repair of DNA double-stranded breaks 1, 2, mitotic DNA synthesis 3, 4, 5 and alternative telomere length maintenance 6, 7. Central to these functions, RAD52 promotes...

6 天之前 · Human RAD52 is a multifunctional DNA repair protein involved in several cellular events that support genome stability, including protection of stalled DNA replication forks from excessive ...

2018年10月26日 · Rad52 is among the most important proteins for genome maintenance in yeast, but it seemed mysteriously inconsequential for DNA repair in higher eukaryotes. However, this viewpoint is...

2025年3月30日 · The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands.

2009年8月25日 · RAD52 is the defining member of an epistasis group of genes involved in repair of ionizing radiation-induced DNA double-strand breaks. Double-strand break repair catalysed by this group of proteins is generally error-free, because genetic information at the double-strand break is restored from an intact copy elsewhere in the genome.

At DNA double-strand breaks, RAD52 was demonstrated to spur alternative pathways to compensate for the loss of homologous recombination functions. At collapsed replication forks, RAD52 activates break-induced replication. In the M phase, RAD52 promotes the finalization of DNA replication.

5 天之前 · Ashley Spies博士合作，发现了有关RAD52的结构和功能信息，这些信息可能有助于他们开发新的特定方法来抑制这种蛋白质。 双环结构保护DNA. Spies和Pichierri先前已经发现RAD52在保护停滞的DNA复制分叉中很重要。他们的研究表明，RAD52的这种新功能促进了癌细 …

In response to DNA damage, RAD52 promotes the formation of nuclear foci, which seem to correspond to DNA repair sites. This action of RAD52 occurs under cell cycle control, where RAD52 activity increases gradually when cells

6 天之前 · “RAD52 is a coveted drug target for treating cancers that have DNA repair deficiencies, including breast and ovarian cancers, and some glioblastomas,” explains Maria Spies, PhD, professor of biochemistry and molecular biology in the UI Carver College of Medicine, and senior author of the new study that was published April 2 in Nature. “This protein is …