2017年11月9日 · RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.

Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression in a range of organisms. The silencing of a gene is a consequence of degradation of RNA into short RNAs that activate ribonucleases to target homologous mRNA.

The term RNA interference (RNAi) was coined to describe a cellular mechanism that uses the gene's own DNA sequence to turn it off, a process that researchers call silencing. In a wide variety of organisms, including animals, plants, and fungi, RNAi is …

RNA interference (RNAi), regulatory system occurring within eukaryotic cells (cells with a clearly defined nucleus) that controls the activity of genes. RNAi functions specifically to silence, or deactivate, genes.

RNA interference (RNAi) is a regulatory mechanism of most eukaryotic cells that uses small double-stranded RNA (dsRNA) molecules as triggers to direct homology-dependent control of gene activity (Figure 1) (1).

2024年6月26日 · RNA interference (RNAi) or Post-transcriptional gene silencing (PTGS) is a process of gene silencing or sequence-specific mRNA degradation. It is a phenomenon inside a cell (either eukaryotic or prokaryotic) that targets and selects the mRNA strand to cleave off and degrade it, so it will block the synthesis of functional unit protein .

The year 2023 marks the 25th anniversary of the discovery of RNAi. RNAi-based therapeutics enable sequence-specific gene knockdown by eliminating target RNA molecules through complementary base-pairing. A systematic review of published and ongoing ...

RNAi offers selective gene targeting in a species-specific manner. RNAi induced by long dsRNA or unmodified siRNA offers a species-specific biodegradable pesticide. RNAi can be a particularly potent tool against pests that display environmental and systemic RNAi.

RNAi therapeutics is an innovative new class of medicines based on RNA interference (RNAi)—a breakthrough discovery in understanding how genes are regulated naturally within cells. The significance of the discovery of RNAi was recognized with …

6 天之前 · RNAi (RNA interference) is a biological process in which RNA molecules—microRNA (miRNA) and small interfering RNA (siRNA)—inhibit gene expression, typically by binding to messenger RNA (mRNA)...