RIPK1 - Wikipedia
RIPK1 is an enzyme that in humans is encoded by the RIPK1 gene, which is located on chromosome 6. [ 6 ] [ 7 ] [ 8 ] This protein belongs to the Receptor Interacting Protein (RIP) …
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
2020年7月15日 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a master regulator of the cellular decision between pro-survival NF-κB signalling and death in response …
Targeting RIPK1 for the treatment of human diseases - PMC
RIPK1 has emerged as a promising target for a spectrum of human CNS and peripheral pathologies. RIPK1 activity is tightly controlled by multiple layers of regulatory factors that we …
Roles of RIPK1 as a stress sentinel coordinating cell survival and ...
2023年8月11日 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is emerging as a critical stress sentinel that functions as a molecular switch, governing cellular survival,...
RIPK1 Gene - GeneCards | RIPK1 Protein | RIPK1 Antibody
2025年3月30日 · This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell …
Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation
Receptor-interacting serine threonine kinase 1 (RIPK1) is a widely expressed kinase that is essential for limiting inflammation in both mice and humans. Mice lacking RIPK1 die at birth …
RIP kinases as modulators of inflammation and immunity
2018年8月21日 · Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by …
A RIPK1-specific PROTAC degrader achieves potent antitumor …
2024年5月23日 · Mannion et al. describe the development of a RIPK1-selective PROTAC degrader that boosts the immunostimulatory and antitumor activity of radiotherapy (RT) and …
The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell …
2024年7月9日 · RIPK1 regulates cell death via kinase-dependent and kinase-independent mechanisms. Utilizing mice expressing RIPK1 with a point mutation disrupting its death …
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic …
2020年8月20日 · This article reviews RIPK1 biology and disease-associated mutations in RIPK1 signalling pathways, highlighting clinical trials of RIPK1 inhibitors and potential strategies to …