2025年3月30日 · PSMB5 (Proteasome 20S Subunit Beta 5) is a Protein Coding gene. Diseases associated with PSMB5 include Cystic Fibrosis and Parkinson's Disease. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and CDK-mediated phosphorylation and removal of Cdc6.

Proteasome subunit beta type-5 also known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. [5][6][7] This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of ...

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). Cleavage of peptide bonds with very broad specificity.

2018年7月19日 · In this manuscript, we are the first to present and functionally characterize four resistance-inducing PSMB5 mutations from a MM patient under prolonged BOR treatment. Depending on the affected...

2014年5月2日 · Suppression of STAT3 tyrosine phosphorylation coordinately decreased the mRNA and protein levels of the β subunits of the 20 S core complex in DU145 cells. Notably, PSMB5, a molecular target of bortezomib, was shown to be a target of STAT3. Knockdown of STAT3 decreased PSMB5 protein.

PSMB5 has 6,176 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or …

PSMB5 Antibody detects endogenous levels of total PSMB5. AB_2838690 引用格式: Affinity Biosciences Cat# DF6728, RRID:AB_2838690. Unconjugated. The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

【摘要 】 目的探讨蛋白酶体β5 亚单位(PSMB5)基因对多发性骨髓瘤(MM)细胞增殖和硼替佐米(BTZ)耐药的影响及其机制。 方法以MM 细胞株RPMI 8226 细胞和BTZ 耐药细胞株RPMI …

目的 探讨蛋白酶体β5亚单位 (PSMB5)基因对多发性骨髓瘤 (MM)细胞增殖和硼替佐米 (BTZ)耐药的影响及其机制.方法 以MM细胞株RPMI 8226细胞和BTZ耐药细胞株RPMI 8226/BTZ 100 (简称BTZ 100)细胞为研究对象,采用慢病毒转染的方法建立过表达和下调PSMB5表达的MM稳转细胞系;CCK8法检测PSMB5对MM细胞增殖和BTZ耐药性的影响;流式细胞术检测PSMB5对细胞凋亡的影响;Western blot法检测PSMB5对凋亡相关基因Bax、Bcl-2、p-Akt和Cleaved caspase-3表达 …