2024年10月16日 · While the term Pyrogen-free means the absence of pyrogen. Pyrogen is a group of substances that cause a rise in temperature in an animal body. Mainly pyrogens are two types: exogenous and endogenous pyrogens [3]. In other words, pyrogen is a fever-inducing agent produced by bacteria, molds, viruses, and yeasts [4].

2023年6月2日 · Being sterile means being free from microorganisms and being pyrogen-free means being free from fever-causing substances. The difference can be likened to insects and their eggs. Since some insecticides can only kill insects but not their eggs, it is possible for an apartment to be free from insects but not free from their eggs.

是多种革兰氏阴性菌的细胞壁成分，由菌体裂解后释出的毒素，成分为脂多糖。 一般认为内毒素为热原的一种，药品生产的时候通常可以接受：不存在内毒素则不存在热原，因此在生产的时候可能只进行内毒素检测而不进行热原检测。 影响： 热原和内毒素能够刺激机体，引起机体发热。 在制药、临床等领域，为了人的安全，通常对热原和内毒素的量有所要求。 在中国药典中对于热原和内毒素的检测也都给到了明确的方法。 而核酸酶在涉及到分子学实验室的时候，因为其具有分 …

Another source of endotoxins is the Water for Injection (WFI) or pyrogen-free water system. As a general comment, circulating hot water systems (above 75 C) provide the environment least...

2010年5月1日 · 修订的文本引入了新通则“热原性（Pyrogenicity）”，取代了“细菌内毒素（Bacterial endotoxins）”和“热原（Pyrogens）”的要求，并提供了如何选择和实施细菌内毒素检查（BET）或单核细胞活化试验（MAT）的具体指导。

2024年9月30日 · In the pharmaceutical industry, “sterile” and “pyrogen-free” are critical terms, but they represent different standards of safety. Sterility refers to the complete elimination of all living microorganisms, achieved through processes like autoclaving or filtration.

热原（pyrogen）系指注入机体后能引起人体体温异常升高的致热物质。 广义的热原包括细菌性热原、内源性高分子热原、内源性低分子热原及化学热原等。

英文: Syringe and injection needle-Render the syinges and needles pyrogen-free by heating at 250℃ for not less than 30 minutes. 中文: 注射器和注射针头—在250摄氏度下加热至少半小时使注射器和针头无带热源质。 更详细...

Sterile vs. pyrogen-free – it's important to your work and you need to know the difference. First of all, what is a pyrogen? Simply, a pyrogen is any substance that causes a fever. The most commonly thought of pyrogens are bacterial endotoxins and exotoxins, although the host body (human or animal) can also produce pyrogens.

2006年6月20日 · pyrogen-free 是无热原，应该是无菌检查里的一项。质量标准检查里的无菌检查