A pyrin domain (PYD, also known as PAAD/DAPIN) is a protein domain and a subclass of protein motif known as the death fold, the 4th and most recently discovered member of the death domain superfamily (DDF).

NLRP3、AIM2、NLRC4 和 Pyrin 之间关键相互作用的发现代表了一种新的范式，有助于理解这些分子在先天性免疫和炎症小体生物学中的功能，并为 NLRP3、AIM2、NLRC4 和 Pyrin 介导的疾病确定新的治疗靶点。

2023年11月27日 · The discovery of critical interactions among NLRP3, AIM2, NLRC4, and Pyrin represents a new paradigm in understanding the functions of these molecules in innate immunity and inflammasome biology...

MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells (neutrophils, eosinophils and monocytes) that play a role in inflammation and in fighting infection.

2020年9月25日 · 核苷酸结合结构域、富含亮氨酸的重复序列和含热蛋白（pyrin）结构域的蛋白3（NLRP3）可被尼日利亚菌素nigericin）、细胞外ATP和尿酸单钠（MSU）晶体 ...

Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that assembles inflammasome complexes in response to pathogen infections. Mutations in the MEFV gene have been linked to autoinflammatory diseases such as familial Mediterranean fever (FMF) or pyrin-associated autoinfl …

2016年6月6日 · Pyrin forms an inflammasome when mutant or in response to bacterial modification of the GTPase RhoA. We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and...

Pyrin is a cytosolic protein encoded by the gene, predominantly expressed in innate immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that enables the activation and secretion of IL-1β and IL-18. In addition, the Pyrin inflammasome activates Gasdermin D leading to pyroptosis, a highly pro-inflammatory cell death.

Pyrin is a sensor within cells that detects disruptions in cellular balance caused by bacterial toxins, leading to the activation of the pyrin inflammasome involved in inflammatory responses. You might find these chapters and articles relevant to this topic. Brienne A. …