2021年11月27日 · Pyclen-dipicolinate chelates proved to be very efficient chelators for the radiolabeling with β – -emitters such as 90 Y. In this study, a pyclen-dipicolinate ligand functionalized with additional C12 alkyl chains was synthesized.

2020年5月5日 · Characterization of the compounds and complexes synthesized (1 H, 13 C, HRMS, analytical HPLC), absorption and emission spectra, fitting of quantum yield experiments, and exponential lifetime decay measurements

The chromatographic system employs HPLC (Vision HT C18 HL 5 μ 250× 4.6 mm) with H 2 O and MeCN as eluents [isocratic 100% H 2 O (5 min), linear gradient from 0 to 90% MeCN (10 min), isocratic 90% MeCN (5 min)] at a flow rate of 1 mL/min and UV

2022年1月7日 · A new pyclen-3,9-diacetate derivative ligand (H 2 3,9-OPC2A) was synthesized possessing an etheric O-atom opposite to the pyridine ring, to improve the dissociation kinetics of its Mn(II) complex (pyclen = 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene).

2023年6月5日 · 过去，人们合成了基于 Pyclen π 延伸吡啶甲酸天线的镧系元素发光生物探针（LLB），并证明了其非常适合双光子显微镜的光学特性。 这项工作的目的是制定一种策略，设计先前研究的 LLB 的双功能类似物，提供额外的反应性化学基团，使其与生物载体偶联，从而 ...

2018年5月30日 · The first pyclen based ligand bearing two picolinate intra-ligand charge transfer transition antennae and one acetate arm organized in a dissymmetric manner was synthesized for Eu (iii) and Sm (iii) complexation. The europium complex presents an excellent brightness and biphotonic imaging of T24-cells has been.

除了已经描述的配体 L4a 之外，还合成了两种基于 pyclen 的镧系元素螯合剂 L4b 和 L4c，它们带有两个特定的吡啶甲酸双光子天线（为每种目标金属量身定制）和一个以不对称方式排列的醋酸盐臂，形成一个完整的镧系元素发光生物探针家族：[EuL4a]、[SmL4a]、[YbL4b ...

neutralisation of pyclen·3HCl, pyclen oxalate (1) was synthesized in good yield (90%) by acylation with diethyl oxalate in MeOH (Fig. 2). The free amine function was then reacted with methyl 6-(chloromethyl)picolinate to lead quasi-quantitatively to 2. After hydrolysis of the oxalate bridge and

Two pyclen based lanthanide chelators, L4b and L4c, bearing two specific picolinate 2P antennas (tailor-made for each targeted metal) and one acetate arm arranged in a dissymmetrical manner, have been synthesized to form, with the already described ligand L4a, a complete family of lanthanide luminescent bioprobes: [EuL4a], [SmL4a], [YbL4b], [TbL...

2023年6月5日 · 这种生物探针基于pyclen-bearing π-extended picolinate天线，具有良好的光学性能。 研究人员通过在宏环吡啶单元的para位置引入一种主要氨基的合成方案，成功地设计出了一种双功能的生物探针。