2020年4月11日 · We aimed to investigate whether novel imaging using prostate-specific membrane antigen (PSMA) PET-CT might improve accuracy and affect management. Methods: In this multicentre, two-arm, randomised study, we recruited men with biopsy-proven prostate cancer and high-risk features at ten hospitals in Australia.

Prostate-specific membrane antigen (PSMA) based imaging using PET/CT fusion has been increasingly used for patients with recurrent prostate cancer. In the proPSMA study, Dr. Hofman and colleagues set to determine the role of PSMA PET/CT in pre-treatment staging.

Total 302 patients with high-risk prostate cancer were randomized into conventional imaging (n = 152) and 68 Ga-PSMA PET-CT (n = 150) arms. 68 Ga-PSMA PET-CT showed significantly higher accuracy (92% vs. 65%, P < 0.0001), sensitivity (85% vs. 38%), and specificity (98% vs. 91%).

2020年4月11日 · Prostate-specific membrane antigen (PSMA) is a cell-surface glycoprotein overexpressed on prostate cancer cells. Radiolabelled small molecules that bind with affinity to PSMA enable whole-body tumour-specific imaging with PET-CT.

2025年3月27日 · The current updated systematic review and meta-analysis provides updated evidence on the diagnostic and staging accuracy of PSMA PET in PCa. We reported good accuracy of PSMA PET to discriminate csPCa, particularly when added to MRI, but NPV alone is insufficient to omit a biopsy.

Results from a randomised controlled trial – the ProPSMA Study – involving 300 prostate cancer (PC) patients find that 68Ga-PSMA PET-CT is more accurate than current practice of conventional imaging with CT and Bone Scan and recommends that 68Ga-PSMA scans be introduced into routine clinical practice.

2023年7月10日 · The proPSMA trial at ten Australian centers demonstrated increased sensitivity and specificity for PSMA PET/CT compared to conventional imaging regarding metastatic status in primary high-risk prostate cancer patients. A cost-effectiveness analysis showed benefits of PSMA PET/CT over conventional imaging for the Australian setting.

Prostate-specific membrane antigen (PSMA) positron-emission tomography (PET)/computed tomography (CT) is a new whole-body scanning technique that enables visualization of PCa with high contrast.

2020年4月3日 · A prospective randomized multicentre study of the impact of gallium-68 prostate-specific membrane antigen (PSMA) PET/CT imaging for staging high-risk prostate cancer prior to curative-intent surgery or radiotherapy (proPSMA study): clinical trial protocol.

2021年3月29日 · We developed a non-radioactive prodrug, SBPD-1, composed of a small-molecule PSMA-targeting moiety, a cancer-selective cleavable linker, and the microtubule inhibitor monomethyl auristatin E...