B细胞在骨髓中的发育经历了祖B细胞（pro B cell）、前B细胞（pre B cell）、未成熟B细胞（immature B cell）和成熟B细胞（mature B cell）等几个阶段。

Large pre-B cell是成功表达重链并通过B细胞第一个检查点的细胞。每个large pre-B细胞都会经历几轮细胞分裂，产生大约100个含相同μ链的细胞（small pre-B cell）。此时细胞不再表达pre B-cell receptor。RAG基因再次被激活，开始下一轮轻链重组。

末端脱氧核甘酸转移酶（terminal deoxy nucleotidyl transferase，TdT）以及共同型急性淋巴母细胞白血病抗原（common acute lymphoblastic leukaemia antigen，CALLA，即CD10）可表达在前B细胞，进入非成熟B细胞后这两种标志即消失，因此TdT和CD10对于区分前B细胞与B细胞其它发 …

B细胞（B lymphocytes）是哺乳动物体内适应性免疫系统的关键组成部分，负责介导体液免疫反应。 它们通过产生抗体，识别并清除外来病原体如病毒和细菌，在免疫记忆和免疫调节中发挥重要作用。

2021年11月25日 · We use single-cell transcriptomics/proteomics to identify differentially expressed gene networks across B cell development and correlate these networks with subtypes of B cell leukemia. Here...

Joining of a V segment to the D-J H completes the late pro-B cell stage. Pro-B cells become pre-B cells when they express membrane m chains with surrogate light chains in the pre-B receptor. Surrogate L chains resemble actual L chains but are the same on every pre-B cell.

祖B细胞是自我更新能力有限的祖先细胞，可分为early pro-B cell和late pro-B cell。在early pro-B cell阶段发生重链D-J重排，在late pro-B cell阶段发生重链的V-D-J重排。同时表达B系特异标志，如Thy-1+、Tdt+、B200+、mb-1+等分子。但整个pro-B cell阶段B细胞表面没有mIgM的表达。

2014年10月1日 · B cell development occurs through a set of stages defined using surface markers. The earliest B cell progenitor is the pre–pro-B cell, which expresses B220 and has germline Ig genes . Next, pro-B cells rearrange their H chain Igμ genes, and express CD19 under the control of Pax5 . At the pre-B cell stage, cells downregulate CD43, express ...

Early B cell precursors, or pro-B cells, undergo immunoglobulin (Ig) gene rearrangement to generate a unique B cell receptor (BCR). Pro-B cells differentiate into pre-B cells once the successful rearrangement of Ig heavy chain genes (IgH) occurs.

2024年6月12日 · Here we show that large-scale chromatin reorganization distinguishes young and old bone marrow progenitor (pro-) B cells. These changes result in increased interactions at the compartment...