Primary mediastinal B-cell lymphoma, abbreviated PMBL or PMBCL, is a rare type of lymphoma that forms in the mediastinum (the space in between the lungs) and predominantly affects young adults. [1][2][3]

2015年1月1日 · Primary mediastinal B-cell lymphoma (PMBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is putatively derived from a thymic B cell. Accounting for up to 10% of cases of DLBCL, this subtype predominantly affects women in the third and fourth decades of life.

2018年8月23日 · In this article, I review my approach to the treatment of PMBCL, incorporating data from adult and pediatric studies, as well as recent advances in our understanding of the molecular basis of PMBCL. Primary mediastinal B-cell lymphoma (PMBCL) is a rare subtype of non-Hodgkin lymphoma that predominantly occurs in adolescents and young adults (AYAs).

2022年9月1日 · Primary mediastinal large B-cell lymphoma (PMBCL) is a separate entity in the World Health Organization’s classification, based on clinicopathologic features and a distinct molecular signature that overlaps with nodular sclerosis classic Hodgkin lymphoma (cHL).

2025年2月1日 · Primary mediastinal large B-cell lymphoma (PMBL) is a mature aggressive B-cell lymphoma that arises in the anterior mediastinum, likely originating from thymic B cells. Initially considered a subtype of diffuse large B-cell lymphoma, PMBL has since been established as a distinct clinicopathologic entity due to its unique clinical, morphologic ...

Primary Mediastinal B-cell Lymphoma (PMBCL) is a fast-growing (aggressive) lymphoma, so you will need to start treatment quickly – usually within 1-3 weeks of being diagnosed. Treatment may include a combination of different medicines, including chemotherapies, monoclonal antibodies (MABs), immune checkpoint inhibitors (ICIs), and radiation ...

Primary mediastinal large B-cell lymphoma (PMBCL) is a type of non-Hodgkin lymphoma (NHL). It is sometimes called primary thymic mediastinal lymphoma. PMBCL develops when B-cells become abnormal (cancerous). B-cells are white blood cells that normally help fight infection. They are sometimes called B-lymphocytes.

Primary mediastinal large B-cell lymphoma (PMBCL) is an aggressive B-cell lymphoma arising from thymic B-cells having clinicopathologic features distinct from systemic diffuse large B-cell lymphoma (DLBCL). PMBCL comprises 2% to 4% of all non-Hodgkin lymphomas (NHL), 7% of DLBCL and seen predominant …

Primary mediastinal B-cell lymphoma (PMBCL) is a relatively rare lymphoma subtype affecting mainly young adults. Its molecular signature and clinical features resemble classical Hodgkin lymphoma. The optimal chemotherapy for this lymphoma subtype ...

Primary mediastinal B-cell lymphoma (PMBL) is recognized as a unique clinicopathologic entity. It has a predilection for female adolescents and young adults, and is characterized by distinct morphologic, immunophenotypic, and molecular features.