Piribedil is an antiparkinsonian agent and piperazine derivative which acts as a D 2 and D 3 receptor agonist. It also has α 2 -adrenergic antagonist properties. [2][3] The drug has been shown to enhance working memory capacities in normal aging adults. [4]

吡贝地尔又称泰舒达、哌利必地、双哌嘧啶，是临床上常用的一种外周血管和脑血管扩张药，属多巴胺受体激动剂，可单一用药或与左旋多巴联合用药治疗帕金森病，改善老年人智能缺陷所致的某些症状，如注意力和记忆力下降、眩晕、下肢动脉栓塞性疾病所致的间歇性跛行 (2期)的辅助治疗。 视网膜缺陷性发作，改善视敏度，作用类似多巴胺，副作用类似左旋多巴。 另外本品也能改善外周血液循环，对阻塞性或栓塞性眼底病有一定疗效。 [1] 中文名称：吡贝地尔. 中文别名： …

吡贝地尔（INN： piribedil ）是一种抗帕金森病药物和哌嗪衍生物，可作为D 2 和D 3 受体激动剂。 它还具有 α 2 -肾上腺素受体 拮抗剂特性。 [ 2 ] [ 3 ]

2016年10月20日 · Piribedil is a dopamine agonist used with or without levodopa in the treatment of Parkinson's disease. Piribedil has been investigated in Parkinson's Disease. The next evolution of DrugBank is here. Designed for scientists, driven by AI, and powered by real-time insights. This is drug intelligence, redefined.

Piribedil is a piperazine derivative, a dopamine receptor agonist, which has been mainly used for the treatment of depression and Parkinson’s disease. It has also been recommended for the treatment of patients with intermittent claudication, without convincing evidence.

Piribedil is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil is also a α2-adrenoceptors antagonist. Piribedil can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM). Piribedil has the potential for the research of parkinson's disease, circulatory disorders, cancers [1] [2] [3] [4].

主要研究目的：按有关生物等效性试验的规定，选择Les Laboratoires Servier为持证商的吡贝地尔缓释片（商品名：泰舒达，规格：50mg）为参比制剂，对石家庄四药有限公司生产并提供的受试制剂吡贝地尔缓释片（规格：50mg）进行餐后给药人体生物等效性试验，比较受试制剂中药物的吸收速度和吸收程度与参比制剂的差异是否在可接受的范围内，评价两种制剂在餐后给药条件下的生物等效性。 次要研究目的：观察健康受试者口服受试制剂吡贝地尔缓释片（规格：50mg） …

Piribedil | C16H18N4O2 | CID 4850 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2025年3月17日 · 吡贝地尔又称泰舒达、哌利必地、双哌嘧啶，是临床上常用的一种外周血管和脑血管扩张药，属多巴胺受体激动剂，可单一用药或与左旋多巴联合用药治疗帕金森病，改善老年人智能缺陷所致的某些症状，如注意力和记忆力下降、眩晕、下肢动脉栓塞性疾病所致的间歇性跛行 (2期)的辅助治疗。 视网膜缺陷性发作，改善视敏度，作用类似多巴胺，副作用类似左旋多巴。 另外本品也能改善外周血液循环，对阻塞性或栓塞性眼底病有一定疗效。 吡贝地尔可刺激大脑 …

2016年6月25日 · Piribedil acts as a non-ergot partial dopamine D2/D3-selective agonist, blocks alpha2-adrenoreceptors and has minimal effects on serotoninergic, cholinergic, and histaminergic receptors. Animal models support the efficacy of piribedil to improve parkinsonian motor symptoms with a lower propensity than levodopa to induce dyskinesia.