Pirfenidone, sold under the brand name Pirespa among others, is a medication used for the treatment of idiopathic pulmonary fibrosis. It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.

2024年10月11日 · Pirfenidone (brand name Esbriet) may be used to treat adults with idiopathic pulmonary fibrosis (IPF), a lung condition that causes inflammation and scarring in the lungs. Pirfenidone’s mechanism of action involves slowing down the build-up of scar tissue in the lungs.

PFD是一种有效的细胞因子抑制剂，通过调节或抑制某些因子，抑制成纤维细胞的生物学活性，减少细胞增殖和基质胶原合成。 同时，PFD 还可抑制炎性介质分泌、减少脂质过氧化等，发挥其抗炎和抗氧化作用。 [1] 1、抑制胶原合成：纤维细胞生长因子（bFGF）、转化生长因子-β 、结缔组织生长因子和金属蛋白酶组织抑制剂-1是与纤维化疾病有关、能够促进成纤维细胞增殖和生长、增加基质胶原的合成以及阻止细胞外基质（ECM）降解的生长因子，在器官纤维化过程中存在 …

Pirfenidone is used for the treatment of idiopathic pulmonary fibrosis (scarring of the lungs with an unknown cause). Pirfenidone is in a class of medications called pyridones. It works by blocking the action of a certain natural substance in the body that is involved in causing fibrosis. How should this medicine be used?

2025年2月1日 · Pirfenidone is used to treat idiopathic pulmonary fibrosis. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.

Pirfenidone is a novel agent with anti-inflammatory, antioxidant, and antifibrotic properties. It may improve lung function and reduce the number of acute exacerbations in patients with idiopathic pulmonary fibrosis (IPF). 9.

2014年5月29日 · In two of three phase 3 trials, pirfenidone, an oral antifibrotic therapy, reduced disease progression, as measured by the decline in forced vital capacity (FVC) or vital capacity, in patients with...

Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia.

Pirfenidone (AMR69) 是一种抗纤维化剂，可减弱纤维细胞中 CCL2 和 CCL12 的产生。 Pirfenidone 具有抑制细胞生长的作用，并能降低人胶质瘤细胞系中的 TGF-β2 蛋白水平。 Pirfenidone 还具有抗炎活性。 * Please select Quantity before adding items. • Eur Respir J. 2025 Jan 9:2400615. [Abstract] • Bioact Mater. 2024 Mar, 33, Pages 262-278. • Mol Ther-Nucl Acids. 2023 Mar 9. • Clin Transl Med. 2022 Oct;12 (10):e1036.

2024年6月10日 · Antifibrotic agent; synthetic pyridone. Treatment of idiopathic pulmonary fibrosis (IPF); designated an orphan drug by FDA for this use.